Literature summary for 2.8.1.7 extracted from

Fosset, C.; Chauveau, M.J.; Guillon, B.; Canal, F.; Drapier, J.C.; Bouton, C.
RNA silencing of mitochondrial m-Nfs1 reduces Fe-S enzyme activity both in mitochondria and cytosol of mammalian cells (2006), J. Biol. Chem., 281, 25398-25406.

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Protein Variants

Protein Variants	Comment	Organism
additional information	depletion of enzyme by gene silencing inhibits the activities of mitochondrial NADH-ubiquinone oxidoreductase and succinate-ubiquinone oxidoreductase of the respiratory chain, as well as aconitase of the Krebs cycle, with no alteration in their protein levels. in addition, activity of cytosolic xanthine oxidase is reduced and iron-regulatory protein-1 is converted from its 4Fe-4S aconitase form to its apo- or RNA-binding form	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9Z1J3	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast	cultured fibroblast	Mus musculus	-

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Release 2023.1 (January 2023)