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Literature summary for 2.8.1.4 extracted from

  • Dewez, M.; Bauer, F.; Dieu, M.; Raes, M.; Vandenhaute, J.; Hermand, D.
    The conserved wobble uridine tRNA thiolase Ctu1-Ctu2 is required to maintain genome integrity (2008), Proc. Natl. Acad. Sci. USA, 105, 5459-5464.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.1.4

Protein Variants

Protein Variants Comment Organism
additional information Ctu1 (cytosolic tRNA thiouridilase) associates with the conserved Ctu2 protein and this complex is the wobble uridine-34 thiolase of cytosolic tRNAs in eukaryotes, the complex is essential to maintaining genome stability Schizosaccharomyces pombe
additional information Ctu1 (cytosolic tRNA thiouridylase) associates with the conserved Ctu2 protein and this complex is the wobble uridine-34 thiolase of cytosolic tRNAs in eukaryotes, the complex is essential to maintaining genome stability Caenorhabditis elegans
additional information single or double deletion mutants of the fission yeast ctu1 and ctu2 genes results in a thermosensitive lethal phenotype reminiscent of the inactivation of their worm counterparts Schizosaccharomyces pombe

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Caenorhabditis elegans Ctu1 (cytosolic tRNA thiouridilase) associates with the conserved Ctu2 protein and this complex is the wobble uridine-34 thiolase of cytosolic tRNAs in eukaryotes, 2-thiouridylation of tRNAs ?
-
 ?
additional information Schizosaccharomyces pombe Ctu1 (cytosolic tRNA thiouridilase) associates with the conserved Ctu2 protein and this complex is the wobble uridine-34 thiolase of cytosolic tRNAs in eukaryotes, 2-thiouridylation of tRNAs ?
-
 ?
additional information Caenorhabditis elegans tRNA (LYS), but not the tRNA (MET), which has a C at position 34, is thiolated in vivo ?
-
 ?
additional information Schizosaccharomyces pombe tRNA (LYS), but not the tRNA (MET), which has a C at position 34, is thiolated in vivo ?
-
 ?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans O76365 Ctu1; gene F29C4.6
-
Schizosaccharomyces pombe O94282 Ctu1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Ctu1 (cytosolic tRNA thiouridilase) associates with the conserved Ctu2 protein and this complex is the wobble uridine-34 thiolase of cytosolic tRNAs in eukaryotes, 2-thiouridylation of tRNAs Caenorhabditis elegans ?
-
 ?
additional information Ctu1 (cytosolic tRNA thiouridilase) associates with the conserved Ctu2 protein and this complex is the wobble uridine-34 thiolase of cytosolic tRNAs in eukaryotes, 2-thiouridylation of tRNAs Schizosaccharomyces pombe ?
-
 ?
additional information tRNA (LYS), but not the tRNA (MET), which has a C at position 34, is thiolated in vivo Caenorhabditis elegans ?
-
 ?
additional information tRNA (LYS), but not the tRNA (MET), which has a C at position 34, is thiolated in vivo Schizosaccharomyces pombe ?
-
 ?

Synonyms

Synonyms Comment Organism
Ctu1
-
 Caenorhabditis elegans
Ctu1
-
 Schizosaccharomyces pombe
thiouridylase
-
 Caenorhabditis elegans
thiouridylase
-
 Schizosaccharomyces pombe
tRNA thiolase
-
 Caenorhabditis elegans
tRNA thiolase
-
 Schizosaccharomyces pombe
wobble uridine-34 thiolase
-
 Caenorhabditis elegans
wobble uridine-34 thiolase
-
 Schizosaccharomyces pombe