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Literature summary for 2.8.1.2 extracted from

  • Nagahara, N.; Katayama, A.
    Post-translational regulation of mercaptopyruvate sulfurtransferase via a low redox potential cysteine-sulfenate in the maintenance of redox homeostasis (2005), J. Biol. Chem., 280, 34569-34576.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
C154S SH group titration, susceptibility to hydrogen peroxide and tetrathionate and renaturation by dithiothreitol similar to wild-type Rattus norvegicus
C247S SH group titration, susceptibility to hydrogen peroxide and tetrathionate and renaturation by dithiothreitol similar to wild-type Rattus norvegicus
C254S SH group titration, susceptibility to hydrogen peroxide and tetrathionate and renaturation by dithiothreitol similar to wild-type Rattus norvegicus
C263S SH group titration, susceptibility to hydrogen peroxide and tetrathionate and renaturation by dithiothreitol similar to wild-type Rattus norvegicus
C64S SH group titration, susceptibility to hydrogen peroxide and tetrathionate and renaturation by dithiothreitol similar to wild-type Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
hydrogen peroxide together with stoichiometric concentration of tetrathionate, renaturation by dithiothreitol or thioredoxin. Excess molar ratio of hydrogen peroxide inactivates Rattus norvegicus
iodoacetate
-
Rattus norvegicus
tetrathionate
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information redox state controls enzyme activity Rattus norvegicus

Renatured (Commentary)

Renatured (Comment) Organism
enzyme inhibited by hydrogen peroxide together with stoichiometric concentration of tetrathionate, complete renaturation by dithiothreitol or thioredoxin Rattus norvegicus

Synonyms

Synonyms Comment Organism
MST
-
Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.12
-
hydrogen peroxide pH 7.4, 0°C Rattus norvegicus
0.178
-
tetrathionate pH 7.4, 0°C Rattus norvegicus