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Literature summary for 2.8.1.11 extracted from

  • Marelja, Z.; Stoecklein, W.; Nimtz, M.; Leimkühler, S.
    A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis (2008), J. Biol. Chem., 283, 25178-25185.
    View publication on PubMed
Search for more literature for 2.8.1.11

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
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 Homo sapiens 5829
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine Homo sapiens
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 AMP + [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + cysteine desulfurase
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O95396
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the two-domain protein MOCS3 catalyzes both the adenylation and the subsequent generation of a thiocarboxylate group at the C-terminus of MOCS2A by its C-terminal rhodanese-like domain (RLD), low activity ofMOCS3-RLD with thiosulfate as sulfur donor Homo sapiens ?
-
 ?
[molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine
-
 Homo sapiens AMP + [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + cysteine desulfurase
-
 ?

Synonyms

Synonyms Comment Organism
MOCS3
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 Homo sapiens

General Information

General Information Comment Organism
additional information Nfs1 interacts specifically with MOCS3-RLD and sulfur is transferred from L-cysteine to MOCS3-RLD via an Nfs1-bound persulfide intermediate. Cytosolic Nfs1 has an important role in sulfur transfer for the biosynthesis of Moco. Isd11 functions as an adapter and stabilizer of Nfs1. Sulfur transfer mechanism, overview Homo sapiens
physiological function the human MOCS3 gene encodes a protein involved in activation and sulfuration of the C-terminus of MOCS2A, the smaller subunit of the molybdopterin (MPT) synthase. MPT synthase catalyzes the formation of the dithiolene group of MPT that is required for the coordination of the molybdenum atom in the last step of molybdenum cofactor (Moco) biosynthesis. The L-cysteine desulfurase Nfs1 might be involved in the sulfuration ofMOCS3 in vivo. Sulfur transfer mechanism, overview Homo sapiens