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Literature summary for 2.8.1.10 extracted from
- Biosynthesis of the thiamin-thiazole in eukaryotes: identification of a thiazole tautomer intermediate (2008), J. Am. Chem. Soc., 130, 11394-11398.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-[sulfur-carrier protein ThiS] = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O | final step of the thiamin-thiazole biosynthesis is the concersion of a labile adenylated thiazole tautomer to the adenylated thiazole product. The conversion has an absolute requirement for enzyme catalysis | Saccharomyces cerevisiae |
a
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