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Literature summary for 2.8.1.1 extracted from

  • Wilson, K.; Mudra, M.; Furne, J.; Levitt, M.
    Differentiation of the roles of sulfide oxidase and rhodanese in the detoxification of sulfide by the colonic mucosa (2007), Dig. Dis. Sci., 53, 277-283.
    View publication on PubMed

Application

Application Comment Organism
medicine thiosulfate sulfurtransferase does not metabolize sulfide. The rate limiting step in sulfide detoxification is oxidation by a sulfide oxidase to thiosulfate, therefor the use of thiosulfate sulfurtransferase activity to determine the rate that colonic mucosa detoxifies sulfide is inappropriate Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bos taurus enzyme does not metabolize sulfide. The rate limiting step in sulfide detoxification is oxidation by a sulfide oxidase to thiosulfate ?
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colon
-
Bos taurus
-
mucosa
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.26
-
substrate H2S, pH 9.2, 22°C Bos taurus
85.3
-
substrate thiosulfate, pH 9.2, 22°C Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H2S + cyanide very poor substrate Bos taurus ?
-
?
additional information enzyme does not metabolize sulfide. The rate limiting step in sulfide detoxification is oxidation by a sulfide oxidase to thiosulfate Bos taurus ?
-
?
thiosulfate + cyanide
-
Bos taurus sulfite + thiocyanate
-
?