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Literature summary for 2.7.9.3 extracted from
- Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: Is there an autoregulatory mechanism in selenocysteine metabolism? (1996), Proc. Natl. Acad. Sci. USA, 93, 15086-15091.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| DNA sequence determination and analysis | Homo sapiens |
| DNA sequence determination and analysis, chromosomal mapping, expression in COS-7 cells as FLAG tagged enzyme | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + selenide + H2O | Homo sapiens | required for synthesis of selenocysteine and seleno-tRNAs | AMP + selenophosphate + phosphate | - |
? |  |
| ATP + selenide + H2O | Mus musculus | required for synthesis of selenocysteine and seleno-tRNAs | AMP + selenophosphate + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Haemophilus influenzae | - |
DNA sequence comparison | - |
| Homo sapiens | Q99611 | gene selD | - |
| Methanocaldococcus jannaschii | - |
DNA sequence comparison | - |
| Mus musculus | P97364 | gene selD | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant from COS-7 cells as FLAG tagged enzyme | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| FDCP-Mix cl.A4 cell | low expression level | Mus musculus | - |
| kidney | low expression level | Mus musculus | - |
| liver | adult and fetal | Mus musculus | - |
| testis | - |
Mus musculus | - |
| yolk sac | very low expression level | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + selenide + H2O | - |
Haemophilus influenzae | AMP + selenophosphate + phosphate | - |
? | |
| ATP + selenide + H2O | - |
Homo sapiens | AMP + selenophosphate + phosphate | - |
? | |
| ATP + selenide + H2O | - |
Mus musculus | AMP + selenophosphate + phosphate | - |
? | |
| ATP + selenide + H2O | required for synthesis of selenocysteine and seleno-tRNAs | Homo sapiens | AMP + selenophosphate + phosphate | - |
? | |
| ATP + selenide + H2O | required for synthesis of selenocysteine and seleno-tRNAs | Mus musculus | AMP + selenophosphate + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Sps2 | - |
Homo sapiens |
| Sps2 | - |
Mus musculus |
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