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Literature summary for 2.7.9.2 extracted from
- On the mechanism of phosphoenolpyruvate synthetase (PEPs) and its inhibition by sodium fluoride: potential magnesium and aluminum fluoride complexes of phosphoryl transfer (2015), Biochem. Cell Biol., 93, 236-240.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | the enzyme is of interest as a target for antibiotic development | Escherichia coli |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| AlCl3 | decreases enzyme substrate binding and turnover | Escherichia coli |  |
| Sodium fluoride | inhibition through the formation of a MgF3- complex within the enzyme active site | Escherichia coli | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Escherichia coli | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + pyruvate + H2O | Escherichia coli | - |
AMP + phosphoenolpyruvate + phosphate | - |
ir | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | P23538 | - |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + pyruvate + H2O = AMP + phosphoenolpyruvate + phosphate | phosphoenolpyruvate synthase catalyzes the conversion of pyruvate to phosphoenolpyruvate (PEP) using a two-step mechanism invoking a phosphorylated-His intermediate | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + pyruvate + H2O | - |
Escherichia coli | AMP + phosphoenolpyruvate + phosphate | - |
ir | |
| ATP + pyruvate + H2O | phospho-transfer mechanism, overview | Escherichia coli | AMP + phosphoenolpyruvate + phosphate | - |
ir | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PEPS | - |
Escherichia coli |
| phosphoenolpyruvate synthase | - |
Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Escherichia coli | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | formation of phosphoenolpyruvate is an initial step in gluconeogenesis | Escherichia coli |
| physiological function | the enzyme is essential for growth of Escherichia coli on 3-carbon sources such as pyruvate. The production of phosphoenolpyruvate synthase has also been linked to bacterial virulence and antibiotic resistance | Escherichia coli |
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Release 2023.1 (January 2023)
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