Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.8.7 extracted from

  • Kosa, N.M.; Foley, T.L.; Burkart, M.D.
    Fluorescent techniques for discovery and characterization of phosphopantetheinyl transferase inhibitors (2014), J. Antibiot., 67, 113-120.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.8.7

Cloned(Commentary)

Cloned (Comment) Organism
gene AASDHPPT, recombinant expression of the Sfp-PPTase from plasmid pET29b in Escherichia coli strain BL21(DE3) Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CoA-[4'-phosphopantetheine] + apo-[acyl-carrier protein] Homo sapiens
-
 adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NRN7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CoA-[4'-phosphopantetheine] + apo-[acyl-carrier protein]
-
 Homo sapiens adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
-
 ?
additional information development of a direct and continuous assay for this enzyme class based upon monitoring polarization of a fluorescent phosphopantetheine analogue as it is transferred from a low molecular weight coenzyme A substrate to higher molecular weight protein acceptor, utility of the method for the biochemical characterization of phosphopantetheinyl transferase Sfp, a canonical enzyme, recombinant enzyme with substrates VibB and 90 amino acid ACP (hACP) from human fatty acid synthase, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
AASDHPPT
-
 Homo sapiens
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase UniProt Homo sapiens
phosphopantetheinyl transferase
-
 Homo sapiens
PPTase
-
 Homo sapiens
Sfp
-
 Homo sapiens
Sfp-PPTase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.7
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function phosphopantetheinyl transferase activates biosynthetic pathways that synthesize both primary and secondary metabolites in bacteria Homo sapiens