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Literature summary for 2.7.8.7 extracted from

  • Mootz, H.D.; Schoergendorfer, K.; Marahiel, M.A.
    Functional characterization of 4'-phosphopantetheinyl transferase genes of bacterial and fungal origin by complementation of Saccharomyces cerevisiae lys5 (2002), FEMS Microbiol. Lett., 213, 51-57.
    View publication on PubMed
Search for more literature for 2.7.8.7

Cloned(Commentary)

Cloned (Comment) Organism
PPTase gene gsp complemented the lys5 deletion in Saccharomyces cerevisiae Brevibacillus brevis
PPtase gene npgA complements the lys5 deletion in Saccharomyces cerevisiae Aspergillus nidulans
PPtase gene q10474, the putative lys7 gene, complements the lys5 deletion in Saccharomyces cerevisiae Schizosaccharomyces pombe
PPTase gene Sfp and Gsp complemented the lys5 deletion in Saccharomyces cerevisiae Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CoA + apo-[acyl-carrier protein] Bacillus subtilis
-
 adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
-
 r
CoA + apo-[acyl-carrier protein] Saccharomyces cerevisiae posttranslational conversion of the alpha-aminoadipate semialdehyde reductase Lys2 in lysine biosynthesis adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
-
 r
CoA + apo-[alpha-aminoadipate semialdehyde reductase Lys2] Saccharomyces cerevisiae
-
 adenosine 3',5'-bisphosphate + holo-[alpha-aminoadipate semialdehyde reductase Lys2]
-
 r

Organism

Organism UniProt Comment Textmining
Aspergillus nidulans
-
-
-
Aspergillus nidulans FGSC4
-
-
-
Bacillus subtilis
-
-
-
Brevibacillus brevis
-
-
-
no activity in Saccharomyces cerevisiae
-
 yeast, strain lys5
-
Saccharomyces cerevisiae
-
-
-
Saccharomyces cerevisiae
-
 yeast
-
Schizosaccharomyces pombe
-
 strain ATCC24843
-
Schizosaccharomyces pombe ATCC 24843
-
 strain ATCC24843
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CoA + apo-[acyl-carrier protein]
-
 Bacillus subtilis adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
-
 r
CoA + apo-[acyl-carrier protein]
-
 Saccharomyces cerevisiae adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
-
 r
CoA + apo-[acyl-carrier protein] posttranslational conversion of the alpha-aminoadipate semialdehyde reductase Lys2 in lysine biosynthesis Saccharomyces cerevisiae adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
-
 r
CoA + apo-[alpha-aminoadipate semialdehyde reductase Lys2]
-
 Saccharomyces cerevisiae adenosine 3',5'-bisphosphate + holo-[alpha-aminoadipate semialdehyde reductase Lys2]
-
 r

Synonyms

Synonyms Comment Organism
4'-phosphopantetheinyl transferase
-
 Saccharomyces cerevisiae