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Literature summary for 2.7.8.6 extracted from
- Biosynthesis of bacterial lipopolysaccharide. VII. Enzymatic formation of the first intermediate in biosynthesis of the O-antigen of Salmonella typhimurium (1968), J. Biol. Chem., 243, 5145-5152.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CMP | 1 mM: 1% inhibition | Salmonella enterica subsp. enterica serovar Typhimurium |  |
| dUMP | 0.13 mM: 48% inhibition, 0.37 mM: 78% inhibition, 1 mM: 87% inhibition | Salmonella enterica subsp. enterica serovar Typhimurium | |
| GMP | 1 mM: 5% inhibition | Salmonella enterica subsp. enterica serovar Typhimurium | |
| TMP | 1.1 mM: 12% inhibition | Salmonella enterica subsp. enterica serovar Typhimurium | |
| UDP | 0.12 mM: no inhibition, 1 mM: 40% inhibition | Salmonella enterica subsp. enterica serovar Typhimurium | |
| UMP | 0.04 mM: 56% inhibition, 0.1 mM: 76% inhibition, 0.4 mM: 93% inhibition | Salmonella enterica subsp. enterica serovar Typhimurium | |
| UTP | 0.11 mM: 5% inhibition, 1 mM: 49% inhibition | Salmonella enterica subsp. enterica serovar Typhimurium | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell envelope | - |
Salmonella enterica subsp. enterica serovar Typhimurium | 30313 | - |
| cell envelope | - |
Citrobacter sp. | 30313 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Citrobacter sp. | - |
- |
- |
| Citrobacter sp. 139 | - |
- |
- |
| Salmonella enterica subsp. enterica serovar Typhimurium | - |
LT-2, mutant strain G30 | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -18°C, stable for at least 1 month | Salmonella enterica subsp. enterica serovar Typhimurium |
| -18°C, stable for at least 1 month | Citrobacter sp. |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDPgalactose + phospholipid | - |
Citrobacter sp. | UMP + galactose-1-diphospho-lipid | - |
r | |
| UDPgalactose + phospholipid | equilibrium constant 0.5 | Salmonella enterica subsp. enterica serovar Typhimurium | UMP + galactose-1-diphospho-lipid | - |
r | |
| UDPgalactose + phospholipid | - |
Citrobacter sp. 139 | UMP + galactose-1-diphospho-lipid | - |
r | |
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