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Literature summary for 2.7.8.5 extracted from

  • Morita, S.Y.; Terada, T.
    Enzymatic measurement of phosphatidylglycerol and cardiolipin in cultured cells and mitochondria (2015), Sci. Rep., 5, 11737.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.8.5

Cloned(Commentary)

Cloned (Comment) Organism
gene PGS1, quantitative PCR enzyme expression analysis, recombinant overexpression of FLAG-tagged PGS1 in HEK-293 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CDP-diacylglycerol + sn-glycerol 3-phosphate Homo sapiens
-
 CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q32NB8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
skeletal muscle
-
 Homo sapiens
-
testis highest expression level of PGS1 mRNA Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CDP-diacylglycerol + sn-glycerol 3-phosphate
-
 Homo sapiens CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PGP synthase 1
-
 Homo sapiens
PGS1
-
 Homo sapiens
phosphatidylglycerophosphate synthase 1
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction overexpression of phosphatidylglycerophosphate synthase 1, PGS1, increases the cellular contents of phosphatidylglycerol, cardiolipin, and phosphatidylcholine, and reduces that of phosphatidic acid. PGS1 overexpression also elevates the mitochondrial contents of cardiolipin and phosphatidylcholine, but has no effect on the number of mitochondria per cell Homo sapiens
metabolism in mammalian cells, phosphatidylglycerol is produced from CDP-diacylglycerol (CDP-DAG) through two steps catalyzed by phosphatidylglycerophosphate (PGP) synthase and PGP phosphatase. CDP-DAG is formed from phosphatidic acid (PA) by the enzymes CDP-DAG synthase 1 and 2, which are integral membrane proteins located to mitochondria and endoplasmic reticulum. CDP-DAG is converted to PGP by the action of the mitochondrial enzyme PGP synthase 1 (PGS1) through the exchange of glycerol-3-phosphate (G3P) with CMP moiety of CDP-DAG. Phosphatidylglycerophosphate is rapidly dephosphorylated to generate phosphatidylglycerol Homo sapiens