BRENDA - Enzyme Database show
show all sequences of 2.7.8.45

Lesions in teichoic acid biosynthesis in Staphylococcus aureus lead to a lethal gain of function in the otherwise dispensable pathway

DElia, M.A.; Pereira, M.P.; Chung, Y.S.; Zhao, W.; Chau, A.; Kenney, T.J.; Sulavik, M.C.; Black, T.A.; Brown, E.D.; J. Bacteriol. 188, 4183-4189 (2006)

Data extracted from this reference:

Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Staphylococcus aureus
Q2G1C1
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Staphylococcus aureus NCTC 8325
Q2G1C1
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-
General Information
General Information
Commentary
Organism
physiological function
gene product TarF is essential for viability. Staphylococcus aureus shows a lethal gain-of-function mechanism where lesions beyond the initial step in wall teichoic acid biosynthesis render Staphylococcus aureus nonviable
Staphylococcus aureus
General Information (protein specific)
General Information
Commentary
Organism
physiological function
gene product TarF is essential for viability. Staphylococcus aureus shows a lethal gain-of-function mechanism where lesions beyond the initial step in wall teichoic acid biosynthesis render Staphylococcus aureus nonviable
Staphylococcus aureus
Other publictions for EC 2.7.8.45
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
740298
Brown
Staphylococcus aureus and Baci ...
Staphylococcus aureus, Staphylococcus aureus NCTC 8325
Chem. Biol.
17
1101-1110
2010
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740296
Brown
a revised pathway proposed for ...
Staphylococcus aureus, Staphylococcus aureus NCTC 8325
Chem. Biol.
15
12-21
2008
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1
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4
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740607
DElia
Lesions in teichoic acid biosy ...
Staphylococcus aureus, Staphylococcus aureus NCTC 8325
J. Bacteriol.
188
4183-4189
2006
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