Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
periplasm | LptA is the only component of the Lpt system that lacks a transmembrane component, as it spans the periplasmic space between the inner membrane and outer membrane complexes. LptA is bound to other Lpt components rather than floating freely in the periplasm | Escherichia coli | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P0ADV1 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | specific LPS interactions with LptA and LptC | Escherichia coli | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
oligomer | the enzyme LptA arranges in an end-to-end fibrous tetramer, which forms a continuous hydrophobic groove between the LptA monomers, crystal structure analysis. Mass spectral analysis confirmes that LptA forms 2-5-member oligomers in a concentration-dependent manner when purified in vitro and that the resultant complexes are stabilized by LPS. Analysis of subunit interactions | Escherichia coli |
Synonyms | Comment | Organism |
---|---|---|
LptA | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
physiological function | the LPS (lipopolysaccharide) transport (Lpt) system, a coordinated seven-subunit protein complex that spans the cellular envelope. LPS transport is driven by an ATPase-dependent mechanism dubbed the PEZ model, whereby a continuous stream of LPS molecules is pushed from subunit to subunit, functional significance of LptA oligomerization and LptC. The membrane-bound LptB, F, G and C subunits are connected to the LptD/E heterodimer in the outer membrane by periplasmic LptA. The LptB2FG tetramer extracts LPS from the outer leaflet of the inner membrane and provides the energy to drive LPS transport through an ATPase-dependent mechanism. LptA provides a continuous LPS binding surface that conveys it to the outer membrane. Mechanism of the LPS (lipopolysaccharide) transport (Lpt) system, specific LPS interactions with LptA and LptC, LptC is the intermediate between the inner membrane complex and LptA, overview | Escherichia coli |