Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.8.43 extracted from

  • Knirel, Y.A.; Lan, R.; Senchenkova, S.N.; Wang, J.; Shashkov, A.S.; Wang, Y.; Perepelov, A.V.; Xiong, Y.; Xu, J.; Sun, Q.
    O-antigen structure of Shigella flexneri serotype Yv and effect of the lpt-O gene variation on phosphoethanolamine modification of S. flexneri O-antigens (2013), Glycobiology, 23, 475-485.
    View publication on PubMed
Search for more literature for 2.7.8.43

Cloned(Commentary)

Cloned (Comment) Organism
gene lpt-O Shigella flexneri

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
diacylphosphatidylethanolamine + O-antigen serotype 4av Shigella flexneri
-
 diacylglycerol + O-antigen serotype 4av (2-aminoethyl diphosphate) the serotype 4av O-antigen has the phosphoethanolamine at position 3 of RhaIII (major) or both RhaII and RhaIII (minor) ?
diacylphosphatidylethanolamine + O-antigen serotype Xv Shigella flexneri
-
 diacylglycerol + O-antigen serotype Xv (2-aminoethyl diphosphate) the serotype Xv O-antigen has the phosphoethanolamine on RhaII ?
diacylphosphatidylethanolamine + O-antigen serotype Yv Shigella flexneri
-
 diacylglycerol + O-antigen serotype Yv 3-(2-aminoethyl diphosphate) the serotype Yv O-antigen has the same basic carbohydrate backbone structure as that of the classical serotype Y, but differs in the presence of phosphoethanolamine at position 3 of RhaIII (major) or both RhaII and RhaIII (minor) ?

Organism

Organism UniProt Comment Textmining
Shigella flexneri S4UV19 several different strains
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
diacylphosphatidylethanolamine + O-antigen serotype 4av
-
 Shigella flexneri diacylglycerol + O-antigen serotype 4av (2-aminoethyl diphosphate) the serotype 4av O-antigen has the phosphoethanolamine at position 3 of RhaIII (major) or both RhaII and RhaIII (minor) ?
diacylphosphatidylethanolamine + O-antigen serotype Xv
-
 Shigella flexneri diacylglycerol + O-antigen serotype Xv (2-aminoethyl diphosphate) the serotype Xv O-antigen has the phosphoethanolamine on RhaII ?
diacylphosphatidylethanolamine + O-antigen serotype Xv
-
 Shigella flexneri diacylglycerol + O-antigen serotype Xv (2-aminoethyl diphosphate) in serotype Yv, mono- and bisphosphorylated O-units generate a block-copolymeric structure, the former being partially O-acetylated at position 6 of GlcNAc and the latter lacking O-acetylation. The serotype Xv O-antigen has the phosphoethanolamine on RhaII ?
diacylphosphatidylethanolamine + O-antigen serotype Yv
-
 Shigella flexneri diacylglycerol + O-antigen serotype Yv 3-(2-aminoethyl diphosphate) the serotype Yv O-antigen has the same basic carbohydrate backbone structure as that of the classical serotype Y, but differs in the presence of phosphoethanolamine at position 3 of RhaIII (major) or both RhaII and RhaIII (minor) ?
additional information NMR spectroscopic analysis of O-antigen substrates and products, detailed overview Shigella flexneri ?
-
 ?

Synonyms

Synonyms Comment Organism
lpt-O
-
 Shigella flexneri
PEtN-transferase
-
 Shigella flexneri

General Information

General Information Comment Organism
physiological function in Shigella flexneri serotype X and 4a variants called Xv and 4av, respectively, O-antigen modification with phosphoethanolamine (PEtN) is identified, which is encoded by a plasmid-borne gene lpt-O for a PEtN-transferase and confers the monoclonal antibody IV-1(MASF IV-1) determinant to the bacteria. A correlation between the serotype-specific PEtN modification pattern and the lpt-O variation in different serotypes: lpt-ORII in serotype Xv is better tuned for phosphorylation of RhaII and lpt-ORIII in serotypes Yv and 4av for phosphorylation of RhaII Shigella flexneri