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Literature summary for 2.7.8.43 extracted from

  • Packiam, M.; Yedery, R.D.; Begum, A.A.; Carlson, R.W.; Ganguly, J.; Sempowski, G.D.; Ventevogel, M.S.; Shafer, W.M.; Jerse, A.E.
    Phosphoethanolamine decoration of Neisseria gonorrhoeae lipid A plays a dual immunostimulatory and protective role during experimental genital tract infection (2014), Infect. Immun., 82, 2170-2179.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.8.43

Protein Variants

Protein Variants Comment Organism
additional information construction of a leptA knockout mtant Neisseria gonorrhoeae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
diacylphosphatidylethanolamine + lipid A Neisseria gonorrhoeae
-
 diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
 ?
diacylphosphatidylethanolamine + lipid A Neisseria gonorrhoeae FA 1090
-
 diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
 ?

Organism

Organism UniProt Comment Textmining
Neisseria gonorrhoeae
-
 gene lptA
-
Neisseria gonorrhoeae FA 1090
-
 gene lptA
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
diacylphosphatidylethanolamine + lipid A
-
 Neisseria gonorrhoeae diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
 ?
diacylphosphatidylethanolamine + lipid A
-
 Neisseria gonorrhoeae FA 1090 diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
 ?

Synonyms

Synonyms Comment Organism
PEA transferase A
-
 Neisseria gonorrhoeae

General Information

General Information Comment Organism
malfunction wild-type Neisseria gonorrhoeae strain FA1090 has a survival advantage relative to a PEA transferase A (lptA) mutant in the human urethral-challenge and murine lower genital tract infection models. Purified lipooligosaccharide containing lipid A devoid of the phosphoethanolamine modification and an lptA mutant of strain FA19 induce significantly lower levels of NF-kappaB in human embryonic kidney Toll-like receptor 4 (TLR4) cells and murine embryonic fibroblasts than wild-type lipooligosaccharide of the parent strain. Vaginal proinflammatory cytokines and chemokines are not elevated in female mice infected with the isogenic lptA mutant, in contrast to mice infected with the wild-type and complemented lptA mutant bacteria. lptA mutant bacteria are more susceptible to human and murine cathelicidins due to increased binding by these peptides and that the differential induction of NF-kappaB by wild-type and unmodified lipid A is more pronounced in the presence of cationic antimicrobial peptides. Wild-type but not lptA mutant gonococci induce a proinflammatory response during infection Neisseria gonorrhoeae
physiological function wild-type Neisseria gonorrhoeae strain FA1090 has a survival advantage relative to a PEA transferase A (lptA) mutant in the human urethral-challenge and murine lower genital tract infection models. Wild-type lipid A stimulates the humanTLR4-MD2-CD14 complex Neisseria gonorrhoeae