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Literature summary for 2.7.8.43 extracted from

  • Trombley, M.P.; Post, D.M.; Rinker, S.D.; Reinders, L.M.; Fortney, K.R.; Zwickl, B.W.; Janowicz, D.M.; Baye, F.M.; Katz, B.P.; Spinola, S.M.; Bauer, M.E.
    Phosphoethanolamine transferase LptA in Haemophilus ducreyi modifies lipid A and contributes to human defensin resistance in vitro (2015), PLoS ONE, 10, e0124373.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.8.43

Cloned(Commentary)

Cloned (Comment) Organism
gene HD_0852 or lptA, homology screening and DNA and amino acid sequence determination and analysis [Haemophilus] ducreyi
gene lptA, DNA and amino acid sequence determination and analysis, recombinant expression in Escherichia coli [Haemophilus] ducreyi

Protein Variants

Protein Variants Comment Organism
additional information generation of an lptA deletion mutant strain using plasmid pMEB256, with or without combined deletions of genes ptdA and ptdB [Haemophilus] ducreyi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information [Haemophilus] ducreyi enzyme LptA modifies lipid A with phosphoethanolamine, mass spectrometric analysis. Haemophilus ducreyi lipopolysaccharide contains one phosphoethanolamine on its lipid A and one phosphoethanolamine on its core oligosaccharide ?
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 ?

Organism

Organism UniProt Comment Textmining
[Haemophilus] ducreyi
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 gene lptA
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[Haemophilus] ducreyi Q7VMW0 human-passaged variant of class I clinical isolate 35000
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[Haemophilus] ducreyi ATCC 700724 Q7VMW0 human-passaged variant of class I clinical isolate 35000
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
diacylphosphatidylethanolamine + lipid A
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 [Haemophilus] ducreyi diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
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 ?
diacylphosphatidylethanolamine + lipid A
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 [Haemophilus] ducreyi ATCC 700724 diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
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 ?
diacylphosphatidylethanolamine + lipid A
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 [Haemophilus] ducreyi diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
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 ?
diacylphosphatidylethanolamine + lipid A
-
 [Haemophilus] ducreyi ATCC 700724 diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
 ?
additional information enzyme LptA modifies lipid A with phosphoethanolamine, mass spectrometric analysis. Haemophilus ducreyi lipopolysaccharide contains one phosphoethanolamine on its lipid A and one phosphoethanolamine on its core oligosaccharide [Haemophilus] ducreyi ?
-
 ?

Synonyms

Synonyms Comment Organism
HD_0852
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 [Haemophilus] ducreyi
lipid A PEA transferase
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 [Haemophilus] ducreyi
LptA
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 [Haemophilus] ducreyi
PEA transferase
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 [Haemophilus] ducreyi
phosphoethanolamine transferase
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 [Haemophilus] ducreyi

General Information

General Information Comment Organism
malfunction deletion of two putative PEA transferase genes in Haemophilus ducreyi increases susceptibility to HBD-3 [Haemophilus] ducreyi
physiological function enzyme LptA is required for phosphoethanolamine modification of lipid A and contributes to resistance of the organism against the human antimicrobial peptides alpha-defensin and beta-defensin, mechanism of resistance to alpha-defensins, overview. Gene lptA is not required for survival in vivo [Haemophilus] ducreyi
physiological function phosphoethanolamine transferase LptA in Haemophilus ducreyi modifies lipid A and contributes to human defensin resistance in vitro. The PEA transferase genes confer resistance to alpha and beta-defensins but not to cathelicidin or human serum. Genes lptA is not required for survival in vivo [Haemophilus] ducreyi