Literature summary for 2.7.8.43 extracted from

Gunn, J.S.; Lim, K.B.; Krueger, J.; Kim, K.; Guo, L.; Hackett, M.; Miller, S.I.
PmrA-PmrB-regulated genes necessary for 4-aminoarabinose lipid A modification and polymyxin resistance (1998), Mol. Microbiol., 27, 1171-1182.

Search for more literature for 2.7.8.43

Protein Variants

Protein Variants	Comment	Organism
additional information	JSG435 carries a mutant pmrA locus allele (pmrA505), JSG435 is mutagenized with the transposon Tn10d. Chromosomal mapping of the transposon insertions of the two polymyxin B sensitive strains shows them to be located at 50-52 centisomes (JSG485) and 43-45 centisomes (JSG486), thus eliminating the possibility that mutations in these regulatory loci are responsible for the observed phenotypic change	Salmonella enterica

Organism

Organism	UniProt	Comment	Textmining
Salmonella enterica	Q8Z1P4	serovar Typhimurium, gene pmrA	-
Salmonella enterica 14028s	Q8Z1P4	serovar Typhimurium, gene pmrA	-

Synonyms

Synonyms	Comment	Organism
PmrA	-	Salmonella enterica

General Information

General Information	Comment	Organism
malfunction	JSG435 carries a mutant pmrA locus allele (pmrA505) that results in high level polymyxin resistance, probably due to constitutive expression of PmrA/PmrB-activated genes	Salmonella enterica
metabolism	two unlinked PmrA/PmrB-regulated loci, designated pmrE and pmrF, are identified as necessary for resistance of the organism to polymyxin B and for the addition of aminoarabinose to lipid A. Genes immediately flanking this putative operon are also regulated by PmrA/PmrB and/or have been associated with Salmonella typhimurium polymyxin resistance	Salmonella enterica

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Release 2023.1 (January 2023)