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Literature summary for 2.7.8.43 extracted from

  • Tran, A.X.; Karbarz, M.J.; Wang, X.; Raetz, C.R.H.; McGrath, S.C.; Cotter, R.J.; Trent, M.S.
    Periplasmic cleavage and modification of the 1-phosphate group of Helicobacter pylori lipid A (2004), J. Biol. Chem., 279, 55780-55791.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.8.43

Cloned(Commentary)

Cloned (Comment) Organism
gene Hp0022, DNA and amino acid sequence determination and analysis, recombinant expression in Escherichia coli NovaBlue(DE3) membranes. method optimization Helicobacter pylori

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
diacylphosphatidylethanolamine + lipid A Helicobacter pylori a phosphoethanolamine unit is directly linked to the 1-position of the disaccharide backbone of lipid A ?
-
 ?
diacylphosphatidylethanolamine + lipid A Helicobacter pylori
-
 diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
-
 ?
additional information Helicobacter pylori lipid A of Helicobacter pylori lacks a 4'-phosphate group and is tri- or tetra-acylated with either (R)-3-hydroxystearate (C18) or (R)-3-hydroxypalmitate (C16), the C-1 hydroxyl group of the proximal glucosamine is derivatized with a phosphoethanolamine residue. This is in contrast with the phoshoethanolamine units of Escherichia coli, Salmonella typhimurium, and Neisseria meningitidis, which are attached to the lipid A phosphate group to form a pyrophosphate linkage. A minor lipid A species found in Helicobacter pylori is both bisphosphorylated and hexa-acylated resembling enterobacterial lipid As ?
-
 ?

Organism

Organism UniProt Comment Textmining
Helicobacter pylori O24867 gene Hp0022 or eptA
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
diacylphosphatidylethanolamine + lipid A a phosphoethanolamine unit is directly linked to the 1-position of the disaccharide backbone of lipid A Helicobacter pylori ?
-
 ?
diacylphosphatidylethanolamine + lipid A
-
 Helicobacter pylori diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
-
 ?
additional information lipid A of Helicobacter pylori lacks a 4'-phosphate group and is tri- or tetra-acylated with either (R)-3-hydroxystearate (C18) or (R)-3-hydroxypalmitate (C16), the C-1 hydroxyl group of the proximal glucosamine is derivatized with a phosphoethanolamine residue. This is in contrast with the phoshoethanolamine units of Escherichia coli, Salmonella typhimurium, and Neisseria meningitidis, which are attached to the lipid A phosphate group to form a pyrophosphate linkage. A minor lipid A species found in Helicobacter pylori is both bisphosphorylated and hexa-acylated resembling enterobacterial lipid As Helicobacter pylori ?
-
 ?

Synonyms

Synonyms Comment Organism
Hp0022
-
 Helicobacter pylori
lipid A pEtN transferase
-
 Helicobacter pylori

General Information

General Information Comment Organism
metabolism Hp0021 is the structural gene for the lipid A 1-phosphatase and is required for removal of the 1-phosphate group from mature lipid A in an in vitro assay system Helicobacter pylori
physiological function modification of the 1-phosphate group of Helicobacter pylori lipid A requires two enzymatic steps Helicobacter pylori