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Literature summary for 2.7.8.43 extracted from

  • Tamayo, R.; Choudhury, B.; Septer, A.; Merighi, M.; Carlson, R.; Gunn, J.S.
    Identification of cptA, a PmrA-regulated locus required for phosphoethanolamine modification of the Salmonella enterica serovar typhimurium lipopolysaccharide core (2005), J. Bacteriol., 187, 3391-3399.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.8.43

Cloned(Commentary)

Cloned (Comment) Organism
gene pmrA, sequence comparisons with Neisseria meningitidis phosphoethanolamine phosphotransferases lptA, lpt3, and lpt6 Salmonella enterica
gene pmrC Salmonella enterica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
diacylphosphatidylethanolamine + lipid A Salmonella enterica addition of phosphoethanolamine to the phosphate group at the 1-position of lipid A diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
-
 ?
diacylphosphatidylethanolamine + lipid A Salmonella enterica addition of phosphoethanolamine to the phosphate group at the 4'-position of lipid A diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
 ?
diacylphosphatidylethanolamine + lipid A Salmonella enterica LT2 addition of phosphoethanolamine to the phosphate group at the 1-position of lipid A diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
-
 ?
diacylphosphatidylethanolamine + lipid A Salmonella enterica LT2 addition of phosphoethanolamine to the phosphate group at the 4'-position of lipid A diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
 ?

Organism

Organism UniProt Comment Textmining
Salmonella enterica P36555 serovar Typhimurium, gene pmrC
-
Salmonella enterica Q8Z1P4 serovar Typhimurium, gene pmrA
-
Salmonella enterica LT2 P36555 serovar Typhimurium, gene pmrC
-
Salmonella enterica LT2 Q8Z1P4 serovar Typhimurium, gene pmrA
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
diacylphosphatidylethanolamine + lipid A addition of phosphoethanolamine to the phosphate group at the 1-position of lipid A Salmonella enterica diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
-
 ?
diacylphosphatidylethanolamine + lipid A addition of phosphoethanolamine to the phosphate group at the 1-position of lipid A Salmonella enterica LT2 diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
-
 ?
diacylphosphatidylethanolamine + lipid A addition of phosphoethanolamine to the phosphate group at the 4'-position of lipid A Salmonella enterica diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
 ?
diacylphosphatidylethanolamine + lipid A addition of phosphoethanolamine to the phosphate group at the 4'-position of lipid A Salmonella enterica LT2 diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
 ?

Synonyms

Synonyms Comment Organism
EptA
-
 Salmonella enterica
phosphoethanolamine transferase
-
 Salmonella enterica
PmrA
-
 Salmonella enterica
PmrC
-
 Salmonella enterica
polymyxin resistance protein A
-
 Salmonella enterica
polymyxin resistance protein C
-
 Salmonella enterica

General Information

General Information Comment Organism
metabolism the PmrA-regulated pmrC gene product mediates the addition of phosphoethanolamine to the 1-position of lipid A and affect resistance to polymxin B, while the PmrA-regulated STM4118 (cptA) gene is necessary for the addition of phosphoethanolamine to the lipopolysacchride core, which is not affected by PmrC, overview. The PmrA-regulated pmrC gene product mediates the addition of phosphoethanolamine to the 1-position of lipid A and affect resistance to polymxin B Salmonella enterica
metabolism the two-component regulatory system PmrA/PmrB controls in part the modifications of the Salmonella enterica serovar Typhimurium lipopolysaccharide with the addition of 4-aminoarabinose to the lipid A and phosphoethanolamine to the lipid A and core in response to the in vivo environment Salmonella enterica
physiological function the PmrA-regulated pmrC gene product mediates the addition of phosphoethanolamine to the 1-position of lipid A and affect resistance to polymxin B Salmonella enterica
physiological function the two-component regulatory system PmrA/PmrB controls in part the modifications of the Salmonella enterica serovar Typhimurium lipopolysaccharide with the addition of 4-aminoarabinose to the lipid A and phosphoethanolamine to the lipid A and core in response to the in vivo environment Salmonella enterica