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Literature summary for 2.7.8.43 extracted from

  • Beceiro, A.; Llobet, E.; Aranda, J.; Bengoechea, J.A.; Doumith, M.; Hornsey, M.; Dhanji, H.; Chart, H.; Bou, G.; Livermore, D.M.; Woodford, N.
    Phosphoethanolamine modification of lipid A in colistin-resistant variants of Acinetobacter baumannii mediated by the pmrAB two-component regulatory system (2011), Antimicrob. Agents Chemother., 55, 3370-3379.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene pmrA, genetic organization of the pmrCAB genes, PCR-based expression analysis in colistin sensitive and resistant strains Acinetobacter baumannii

Organism

Organism UniProt Comment Textmining
Acinetobacter baumannii E2FGC2 diverse colistin sensitive and resistant strains, gene pmrA
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Source Tissue

Source Tissue Comment Organism Textmining
additional information colistin resistant strains show higher enzyme expression compared to colistin sensitive strains, enzyme expression analysis, overview Acinetobacter baumannii
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information addition of phosphoethanolamine to hepta-acylated lipid A Acinetobacter baumannii ?
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 ?

Synonyms

Synonyms Comment Organism
PmrA
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 Acinetobacter baumannii

Expression

Organism Comment Expression
Acinetobacter baumannii no upregulation of pmrA by Fe3+ and Mg2+ in strain ATCC 19606 additional information

General Information

General Information Comment Organism
malfunction point mutations in the PmrA/B two-component system lead to colistin resistance Acinetobacter baumannii
metabolism the development of a moderate level of colistin resistance in Acinetobacter baumannii requires distinct genetic events, including (i) at least one point mutation in pmrB, (ii) upregulation of pmrAB, and (iii) expression of pmrC, which lead to addition of phosphoethanolamine to lipid A Acinetobacter baumannii
physiological function phosphoethanolamine modification of lipid A in colistin-resistant variants of Acinetobacter baumannii, e.g. strain ATCC 19606, is mediated by the pmrAB two-component regulatory system Acinetobacter baumannii