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Literature summary for 2.7.8.41 extracted from
- Complex evolution of two types of cardiolipin synthase in the eukaryotic lineage stramenopiles (2016), Mol. Phylogenet. Evol., 101, 133-141.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| CLS_cap, DNA and amino acid sequence determination and analysis, phylogenetic analysis, overview | Wobblia lunata |
| CLS_cap, DNA and amino acid sequence determination and analysis, phylogenetic analysis, overview | Cafeteria roenbergensis |
| CLS_cap, DNA and amino acid sequence determination and analysis, phylogenetic analysis, overview | Developayella elegans |
| CLS_pld, phylogenetic analysis, overview | Cafeteria sp. |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Developayella elegans | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| a CDP-diacylglycerol + a phosphatidylglycerol | Wobblia lunata | - |
a cardiolipin + CMP | - |
? |  |
| a CDP-diacylglycerol + a phosphatidylglycerol | Cafeteria roenbergensis | - |
a cardiolipin + CMP | - |
? | |
| a CDP-diacylglycerol + a phosphatidylglycerol | Developayella elegans | - |
a cardiolipin + CMP | - |
? | |
| a CDP-diacylglycerol + a phosphatidylglycerol | Developayella elegans NIES1388 | - |
a cardiolipin + CMP | - |
? | |
| a CDP-diacylglycerol + a phosphatidylglycerol | Cafeteria roenbergensis NIES1012 | - |
a cardiolipin + CMP | - |
? | |
| a CDP-diacylglycerol + a phosphatidylglycerol | Wobblia lunata NIES1015 | - |
a cardiolipin + CMP | - |
? | |
| a phosphatidylglycerol + a phosphatidylglycerol | Cafeteria sp. | - |
a cardiolipin + glycerol | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cafeteria roenbergensis | - |
- |
- |
| Cafeteria roenbergensis NIES1012 | - |
- |
- |
| Cafeteria sp. | - |
Caron, lab isolate | - |
| Developayella elegans | - |
- |
- |
| Developayella elegans NIES1388 | - |
- |
- |
| Wobblia lunata | - |
- |
- |
| Wobblia lunata NIES1015 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| a CDP-diacylglycerol + a phosphatidylglycerol | - |
Wobblia lunata | a cardiolipin + CMP | - |
? | |
| a CDP-diacylglycerol + a phosphatidylglycerol | - |
Cafeteria roenbergensis | a cardiolipin + CMP | - |
? | |
| a CDP-diacylglycerol + a phosphatidylglycerol | - |
Developayella elegans | a cardiolipin + CMP | - |
? | |
| a CDP-diacylglycerol + a phosphatidylglycerol | - |
Developayella elegans NIES1388 | a cardiolipin + CMP | - |
? | |
| a CDP-diacylglycerol + a phosphatidylglycerol | - |
Cafeteria roenbergensis NIES1012 | a cardiolipin + CMP | - |
? | |
| a CDP-diacylglycerol + a phosphatidylglycerol | - |
Wobblia lunata NIES1015 | a cardiolipin + CMP | - |
? | |
| a phosphatidylglycerol + a phosphatidylglycerol | - |
Cafeteria sp. | a cardiolipin + glycerol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cardiolipin synthase | - |
Wobblia lunata |
| cardiolipin synthase | - |
Cafeteria roenbergensis |
| cardiolipin synthase | - |
Developayella elegans |
| cardiolipin synthase | - |
Cafeteria sp. |
| CL synthase | - |
Wobblia lunata |
| CL synthase | - |
Cafeteria roenbergensis |
| CL synthase | - |
Developayella elegans |
| CL synthase | - |
Cafeteria sp. |
| CLS_cap | - |
Wobblia lunata |
| CLS_cap | - |
Cafeteria roenbergensis |
| CLS_cap | - |
Developayella elegans |
| CLS_cap | - |
Cafeteria sp. |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, and CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, function in bacteria and eukaryotes (mitochondria), respectively. Phylogenetic analysis, overview. Exceptions to the above-mentioned hypothesis regarding CLS phylogenetic distribution, in which CLS_pld and CLS_cap are exclusively found in bacteria and eukaryotes, respectively, are found in actinobacteria and proteobacteria, that contain CLS_cap-like proteins. The eukaryotic supergroups Amoebozoa, Excavata, and Alveolata, a subgroup of the supergroup SAR, have only CLS_pld (without phylogenetic affiliation to any particular bacterial homologues), while the supergroups Opisthokonta (including animals and fungi) and Archaeplastida (including land plants) along with another SAR subgroup stramenopiles possess only CLS_cap (closely related to alpha-proteobacterial homologues). Cafeteria roenbergensis contains only a CLS_cap enzyme homologue, no CLS_pld homologue | Cafeteria roenbergensis |
| evolution | CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, and CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, function in bacteria and eukaryotes (mitochondria), respectively. Phylogenetic analysis, overview. Exceptions to the above-mentioned hypothesis regarding CLS phylogenetic distribution, in which CLS_pld and CLS_cap are exclusively found in bacteria and eukaryotes, respectively, are found in actinobacteria and proteobacteria, that contain CLS_cap-like proteins. The eukaryotic supergroups Amoebozoa, Excavata, and Alveolata, a subgroup of the supergroup SAR, have only CLS_pld (without phylogenetic affiliation to any particular bacterial homologues), while the supergroups Opisthokonta (including animals and fungi) and Archaeplastida (including land plants) along with another SAR subgroup stramenopiles possess only CLS_cap (closely related to alpha-proteobacterial homologues). Cafeteria sp. Caron contains both, a CLS_cap enzyme homologue, and a CLS_pld homologue | Cafeteria sp. |
| evolution | CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, and CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, function in bacteria and eukaryotes (mitochondria), respectively. Phylogenetic analysis, overview. Exceptions to the above-mentioned hypothesis regarding CLS phylogenetic distribution, in which CLS_pld and CLS_cap are exclusively found in bacteria and eukaryotes, respectively, are found in actinobacteria and proteobacteria, that contain CLS_cap-like proteins. The eukaryotic supergroups Amoebozoa, Excavata, and Alveolata, a subgroup of the supergroup SAR, have only CLS_pld (without phylogenetic affiliation to any particular bacterial homologues), while the supergroups Opisthokonta (including animals and fungi) and Archaeplastida (including land plants) along with another SAR subgroup stramenopiles possess only CLS_cap (closely related to alpha-proteobacterial homologues). Developayella elegans contains only a CLS_cap enzyme homologue, no CLS_pld homologue | Developayella elegans |
| evolution | CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, and CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, function in bacteria and eukaryotes (mitochondria), respectively. Phylogenetic analysis, overview. Exceptions to the above-mentioned hypothesis regarding CLS phylogenetic distribution, in which CLS_pld and CLS_cap are exclusively found in bacteria and eukaryotes, respectively, are found in actinobacteria and proteobacteria, that contain CLS_cap-like proteins. The eukaryotic supergroups Amoebozoa, Excavata, and Alveolata, a subgroup of the supergroup SAR, have only CLS_pld (without phylogenetic affiliation to any particular bacterial homologues), while the supergroups Opisthokonta (including animals and fungi) and Archaeplastida (including land plants) along with another SAR subgroup stramenopiles possess only CLS_cap (closely related to alpha-proteobacterial homologues). Wobblia lunata contains both, a CLS_cap enzyme homologue, and a CLS_pld homologue | Wobblia lunata |
| metabolism | cardiolipin is known to be biosynthesized by either of two phylogenetically distinct enzymes: CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, which synthesizes cardiolipin from two molecules of phosphatidylglycerols or CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, which produces this lipid using a phosphatidylglycerol and a cytidine diphosphate diacylglycerol as substrates. In contrast to the bacterial-type CL, mitochondrial immature cardiolipin synthesized by CLS is further remodeled (reacylated), resulting in mature cardiolipin generally possessing the same fatty acids at sn-1, 2 sites in one molecule. This eukaryotic cardiolipin maturation pathway consists of two steps: in the first step, immature ardiolipin is deacylated into monolysocardiolipin (MLCL) with either cardiolipin-specific phospholipase (CLD) or calcium-independent phospholipase A2 (iPLA2) beta/gamma | Cafeteria roenbergensis |
| metabolism | cardiolipin is known to be biosynthesized by either of two phylogenetically distinct enzymes: CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, which synthesizes cardiolipin from two molecules of phosphatidylglycerols or CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, which produces this lipid using a phosphatidylglycerol and a cytidine diphosphate diacylglycerol as substrates. In contrast to the bacterial-type CL, mitochondrial immature cardiolipin synthesized by CLS is further remodeled (reacylated), resulting in mature cardiolipin generally possessing the same fatty acids at sn-1, 2 sites in one molecule. This eukaryotic cardiolipin maturation pathway consists of two steps: in the first step, immature ardiolipin is deacylated into monolysocardiolipin (MLCL) with either cardiolipin-specific phospholipase (CLD) or calcium-independent phospholipase A2 (iPLA2) beta/gamma | Developayella elegans |
| metabolism | cardiolipin is known to be biosynthesized by either of two phylogenetically distinct enzymes: CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, which synthesizes cardiolipin from two molecules of phosphatidylglycerols or CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, which produces this lipid using a phosphatidylglycerol and a cytidine diphosphate diacylglycerol as substrates. In contrast to the bacterial-type CL, mitochondrial immature cardiolipin synthesized by CLS is further remodeled (reacylated), resulting in mature cardiolipin generally possessing the same fatty acids at sn-1, 2 sites in one molecule. This eukaryotic cardiolipin maturation pathway consists of two steps: in the first step, immature ardiolipin is deacylated into monolysocardiolipin (MLCL) with either cardiolipin-specific phospholipase (CLD) or calcium-independent phospholipase A2 (iPLA2) beta/gamma | Cafeteria sp. |
| metabolism | cardiolipin is known to be biosynthesized by either of two phylogenetically distinct enzymes: CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, which synthesizes cardiolipin from two molecules of phosphatidylglycerols or CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, which produces this lipid using a phosphatidylglycerol and a cytidine diphosphate diacylglycerol as substrates. In contrast to the bacterial-type CL, mitochondrial immature cardiolipin synthesized by CLS is further remodeled (reacylated), resulting in mature cardiolipin generally possessing the same fatty acids at sn-1, 2 sites in one molecule. This eukaryotic cardiolipin maturation pathway consists of two steps: in the first step, immature cardiolipin is deacylated into monolysocardiolipin (MLCL) with either cardiolipin-specific phospholipase (CLD) or calcium-independent phospholipase A2 (iPLA2) beta/gamma | Wobblia lunata |
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