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Literature summary for 2.7.8.41 extracted from

  • Hung, C.; Kobayashi, K.; Wada, H.; Nakamura, Y.
    Functional specificity of cardiolipin synthase revealed by the identification of a cardiolipin synthase CrCLS1 in Chlamydomonas reinhardtii (2016), Front. Microbiol., 6, 1542.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene CrCLS1, DNA and amino acid sequence determination and analysis, sequence comparisons, quantitative RT-PCR expression analysis, the gene cannot perform functional complementation of pgsA, a PGPS mutant of Synechocystis sp. PCC6803, but of DELTAcrd1, a CLS mutant of Saccharomyces cerevisiae Chlamydomonas reinhardtii

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial membrane
-
Chlamydomonas reinhardtii 31966
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ required Chlamydomonas reinhardtii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a CDP-diacylglycerol + a phosphatidylglycerol Chlamydomonas reinhardtii
-
a cardiolipin + CMP
-
?
a CDP-diacylglycerol + a phosphatidylglycerol Chlamydomonas reinhardtii CC-503
-
a cardiolipin + CMP
-
?

Organism

Organism UniProt Comment Textmining
Chlamydomonas reinhardtii A8JAW5 cw92mt+
-
Chlamydomonas reinhardtii CC-503 A8JAW5 cw92mt+
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a CDP-diacylglycerol + a phosphatidylglycerol
-
Chlamydomonas reinhardtii a cardiolipin + CMP
-
?
a CDP-diacylglycerol + a phosphatidylglycerol
-
Chlamydomonas reinhardtii CC-503 a cardiolipin + CMP
-
?

Synonyms

Synonyms Comment Organism
cardiolipin synthase
-
Chlamydomonas reinhardtii
CHLREDRAFT_177689
-
Chlamydomonas reinhardtii
CLS
-
Chlamydomonas reinhardtii
CrCLS1
-
Chlamydomonas reinhardtii
Cre13.g604700 locus name Chlamydomonas reinhardtii
phosphatidylglycerophosphate synthase-like protein UniProt Chlamydomonas reinhardtii

General Information

General Information Comment Organism
evolution phosphatidylglycerophosphate synthase (PGPS) and cardiolipin synthase (CLS) are both involved in the biosynthesis of phosphatidylglycerol and cardiolipin and belong to the CDP-alcohol phosphotransferases, they share overall amino acid sequence homology. PGPS and CLS are functionally distinct in vivo. Comparison of CDP-alcohol phosphotransferase motifs between PGPS and CLS among different species reveal a possible additional motif that might define the substrate specificity of the closely related enzymes Chlamydomonas reinhardtii
metabolism cardiolipin synthase is involved in the biosynthesis of cardiolipin Chlamydomonas reinhardtii
physiological function gene CrCLS1 does not complement the growth phenotype of a phosphatidylglycerophosphate synthase (PGPS) mutant of Synechocystis sp. PCC6803, but it rescues the temperature-sensitive growth phenotype, growth profile with different carbon sources, phospholipid composition, and enzyme activity of DELTAcrd1, a cardiolipin synthase (CLS) mutant of Saccharomyces cerevisiae Chlamydomonas reinhardtii