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Literature summary for 2.7.8.41 extracted from
- Solubilization, purification, and characterization of cardiolipin synthase from rat liver mitochondria. Demonstration of its phospholipid requirement (1991), J. Biol. Chem., 266, 22398-22403.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0016 | - |
CDP-dimyristoylglycerol | pH 8.5, 37°C, at optimal concentration of phospholipid activators | Rattus norvegicus |  |
| 0.045 | - |
egg yolk phosphatidylglycerol | pH 8.5, 37°C, at optimal concentration of phospholipid activators | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | mitochondrial membrane | Rattus norvegicus | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | the enzyme displays an absolute requirement for divalent cations with Co2+ being more efficient than Mg2+ or Mn2+ | Rattus norvegicus | |
| KCl | requires KCl concentration of about 0.4 M | Rattus norvegicus | |
| Mg2+ | the enzyme displays an absolute requirement for divalent cations with Co2+ being more efficient than Mg2+ or Mn2+ | Rattus norvegicus | |
| Mn2+ | the enzyme displays an absolute requirement for divalent cations with Co2+ being more efficient than Mg2+ or Mn2+ | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50000 | - |
1 * 50000, SDS-PAGE | Rattus norvegicus |
| 60000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| a CDP-diacylglycerol + a phosphatidylglycerol | Rattus norvegicus | - |
a cardiolipin + CMP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| a CDP-diacylglycerol + a phosphatidylglycerol | - |
Rattus norvegicus | a cardiolipin + CMP | - |
? | |
| CDP-dimyristoylglycerol + egg yolk phosphatidylglycerol | - |
Rattus norvegicus | cardiolipin + CMP | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 50000, SDS-PAGE | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CL synthase | - |
Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | 8.9 | pH 7.2: about 40% of maximal activity, pH 8.9: about 75% of maximal activity | Rattus norvegicus |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Rattus norvegicus | isoelectric point | 5 | 4 |
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