Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.8.36 extracted from

  • Anonsen, J.H.; Vik, A.; Borud, B.; Viburiene, R.; Aas, F.E.; Kidd, S.W.; Aspholm, M.; Koomey, M.
    Characterization of a unique tetrasaccharide and distinct glycoproteome in the O-linked protein glycosylation system of Neisseria elongata subsp. glycolytica (2016), J. Bacteriol., 198, 256-267.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.8.36

Cloned(Commentary)

Cloned (Comment) Organism
gene pglB, DNA and amino acid sequence determination, genetic organization, comparative pgl gene content and synteny between Neisseria elongata subsp. glycolytica strain ATCC 29315 and Neisseria gonorrhoeae strain FA1090. The core pgl locus of Neisseria elongata subsp. glycolytica encompasses pglG, pglH, pglC, and a split (two-ORF) version of pglB, whereas pglF and pglD are localized elsewhere in the genome. The pglO gene is also localized outside the core locus in Neisseria elongata subsp. glycolytica, while the pglA, pglE, and pglI genes are not found in Neisseria elongata subsp. glycolytica Neisseria elongata subsp. glycolytica
gene pglB, DNA and amino acid sequence determination, genetic organization, comparative pgl gene content and synteny between Neisseria elongata subsp. glycolytica strain ATCC 29315 and Neisseria gonorrhoeae strain FA1090. The pglO gene is localized outside the core locus in Neisseria gonorrhoeae Neisseria gonorrhoeae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N,N'-diacetylbacillosamine + tritrans,heptacis-undecaprenyl phosphate Neisseria gonorrhoeae
-
 UMP + N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tritrans,heptacis-undecaprenol
-
 ?
UDP-N,N'-diacetylbacillosamine + tritrans,heptacis-undecaprenyl phosphate Neisseria elongata subsp. glycolytica
-
 UMP + N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tritrans,heptacis-undecaprenol
-
 ?
UDP-N,N'-diacetylbacillosamine + tritrans,heptacis-undecaprenyl phosphate Neisseria gonorrhoeae FA 1090
-
 UMP + N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tritrans,heptacis-undecaprenol
-
 ?
UDP-N,N'-diacetylbacillosamine + tritrans,heptacis-undecaprenyl phosphate Neisseria elongata subsp. glycolytica ATCC 29315
-
 UMP + N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tritrans,heptacis-undecaprenol
-
 ?

Organism

Organism UniProt Comment Textmining
Neisseria elongata subsp. glycolytica
-
-
-
Neisseria elongata subsp. glycolytica ATCC 29315
-
-
-
Neisseria gonorrhoeae
-
-
-
Neisseria gonorrhoeae FA 1090
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N,N'-diacetylbacillosamine + tritrans,heptacis-undecaprenyl phosphate
-
 Neisseria gonorrhoeae UMP + N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tritrans,heptacis-undecaprenol
-
 ?
UDP-N,N'-diacetylbacillosamine + tritrans,heptacis-undecaprenyl phosphate
-
 Neisseria elongata subsp. glycolytica UMP + N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tritrans,heptacis-undecaprenol
-
 ?
UDP-N,N'-diacetylbacillosamine + tritrans,heptacis-undecaprenyl phosphate
-
 Neisseria gonorrhoeae FA 1090 UMP + N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tritrans,heptacis-undecaprenol
-
 ?
UDP-N,N'-diacetylbacillosamine + tritrans,heptacis-undecaprenyl phosphate
-
 Neisseria elongata subsp. glycolytica ATCC 29315 UMP + N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tritrans,heptacis-undecaprenol
-
 ?

Synonyms

Synonyms Comment Organism
pclB
-
 Neisseria gonorrhoeae
pclB
-
 Neisseria elongata subsp. glycolytica

General Information

General Information Comment Organism
metabolism the enzyme is part of the broad-spectrum O-linked glycosylation pathway expressed by neisserial species, overview. PglB, -C, and -D are required for the synthesis of UDP-N'-diacetylbacillosamine (UDP-diNAcBac) and transfer of the phospho-diNAcBac to undecaprenyl phosphate. This glycoform can be further modified by the glycosyltransferases PglA and PglH/PglH2. The PglE glycosyltransferase can modify only the disaccharide glycoform generated by PglA Neisseria gonorrhoeae
metabolism the enzyme is part of the broad-spectrum O-linked glycosylation pathway expressed by neisserial species, overview. PglB, -C, and -D are required for the synthesis of UDP-N'-diacetylbacillosamine (UDP-diNAcBac) and transfer of the phospho-diNAcBac to undecaprenyl phosphate. This glycoform can be further modified by the glycosyltransferases PglA and PglH/PglH2. The PglE glycosyltransferase can modify only the disaccharide glycoform generated by PglA Neisseria elongata subsp. glycolytica
physiological function the PglD and PglC proteins carry out NAD+-dependent dehydratase and aminotransferase reactions, respectively, to convert UDP-GlcNAc to UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha--D-glucose. PglB then acts as a bifunctional enzyme, which catalyzes the amino acetylation of UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucose to form UDP-di-N-acetylbacillosamine (diNAcBac) and the transfer of the phospho-sugar to undecaprenyl phosphate Neisseria gonorrhoeae
physiological function the PglD and PglC proteins carry out NAD+-dependent dehydratase and aminotransferase reactions, respectively, to convert UDP-GlcNAc to UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucose. PglB then acts as a bifunctional enzyme, which catalyzes the amino acetylation of UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucose to form UDP-di-N-acetylbacillosamine (diNAcBac) and the transfer of the phospho-sugar to undecaprenyl phosphate Neisseria elongata subsp. glycolytica