Application | Comment | Organism |
---|---|---|
drug development | enzyme WecA is a promising target for the development of antituberculous drugs as a countermeasure of drug resistant tuberculosis | Mycobacterium tuberculosis |
Cloned (Comment) | Organism |
---|---|
gene wecA, recombinant expression in Mycobacterium smegmatis strain 8a10 | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CPZEN-45 | a caprazamycin derivative, CPZEN-45 shows excellent antitubercular activity against not only drug-sensitive strains but also some multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis strains | Mycobacterium tuberculosis | |
additional information | poor inhibition by caprazamycin B | Mycobacterium tuberculosis | |
tunicamycin | - |
Mycobacterium tuberculosis | |
Vancomycin | weak inhibition | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WMW5 | gene wecA or Rv1302 or Rfe | - |
Mycobacterium tuberculosis H37Rv | P9WMW5 | gene wecA or Rv1302 or Rfe | - |
Synonyms | Comment | Organism |
---|---|---|
decaprenyl-phosphate N-acetylglucosaminephosphotransferase | UniProt | Mycobacterium tuberculosis |
GlcNAc-1-phosphate transferase | - |
Mycobacterium tuberculosis |
WecA | - |
Mycobacterium tuberculosis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00004 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | CPZEN-45 | |
0.004 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | Vancomycin |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is involved in the biosynthesis of the mycolylarabinogalactan of the cell wall of Mycobacterium tuberculosis | Mycobacterium tuberculosis |