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Literature summary for 2.7.8.35 extracted from

  • Xu, L.; Qian, L.; Kang, J.; Sha, S.; Xin, Y.; Lu, S.; Ma, Y.
    Down-regulation of N-acetylglucosamine-1-phosphate transferase (WecA) enhanced the sensitivity of Mycobacterium smegmatis against rifampin (2016), J. Appl. Microbiol., 121, 966-972.
    View publication on PubMed
Search for more literature for 2.7.8.35

Protein Variants

Protein Variants Comment Organism
additional information construction of a Mycobacterium smegmatis wecA knockdown strain by using a tetracycline-inducible expression vector pMind, the expression of WecA is regulated by antisense RNA Mycolicibacterium smegmatis

Inhibitors

Inhibitors Comment Organism Structure
Rifampin the sensitivity of wild-type mc2155 strain against rifampin is enhanced in the presence of low concentrations of tunicamycin, a natural WecA inhibitor. An enzyme knockdown mutant strain also shows increased sensitivity to rifampin Mycolicibacterium smegmatis
tunicamycin
-
 Mycolicibacterium smegmatis

Organism

Organism UniProt Comment Textmining
Mycolicibacterium smegmatis A0R211 gene wecA
-
Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 A0R211 gene wecA
-

Synonyms

Synonyms Comment Organism
MSMEG_4947 locus name Mycolicibacterium smegmatis
N-acetylglucosamine-1-phosphate transferase
-
 Mycolicibacterium smegmatis
WecA
-
 Mycolicibacterium smegmatis

General Information

General Information Comment Organism
malfunction a Mycobacterium smegmatis wecA knockdown strain regulated by antisense RNA has a decreased growth rate and the amount of live bacterial cells drops. In addition, the wecA knockdown strain exhibits dramatically morphological alterations. The wecA knockdown strain is more sensitive to rifampin, compared with the wecA normal-expression strain Mycolicibacterium smegmatis
physiological function wecA is an essential gene for mycobacterial growth Mycolicibacterium smegmatis