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Literature summary for 2.7.8.34 extracted from
- Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles (2007), J. Bacteriol., 189, 5405-5412.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Archaeoglobus fulgidus |
| expression in Escherichia coli | Pyrococcus furiosus |
| expression in Escherichia coli | Thermococcus kodakarensis |
| expression in Escherichia coli | Aquifex aeolicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate | Archaeoglobus fulgidus | the enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments | CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate | - |
? |  |
| CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate | Pyrococcus furiosus | the enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments | CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate | - |
? | |
| CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate | Thermococcus kodakarensis | the enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments | CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate | - |
? | |
| CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate | Aquifex aeolicus | the enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments | CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aquifex aeolicus | O67379 | - |
- |
| Archaeoglobus fulgidus | O29976 | - |
- |
| Pyrococcus furiosus | Q8U1Z6 | - |
- |
| Thermococcus kodakarensis | Q5JDA9 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Archaeoglobus fulgidus |
| partial | Pyrococcus furiosus |
| partial | Thermococcus kodakarensis |
| partial | Aquifex aeolicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate | the enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments | Archaeoglobus fulgidus | CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate | - |
? | |
| CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate | the enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments | Pyrococcus furiosus | CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate | - |
? | |
| CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate | the enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments | Thermococcus kodakarensis | CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate | - |
? | |
| CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate | the enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments | Aquifex aeolicus | CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate | - |
? | |
| CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate | bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase. The cytidylyltransferase is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors | Archaeoglobus fulgidus | CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate | - |
? | |
| CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate | bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase. The cytidylyltransferase is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors | Pyrococcus furiosus | CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate | - |
? | |
| CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate | bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase. The cytidylyltransferase is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors | Thermococcus kodakarensis | CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate | - |
? | |
| CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate | bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase. The cytidylyltransferase is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors | Aquifex aeolicus | CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate | - |
? | |
| CDP-D-myo-inositol + 1L-myo-inositol 1-phosphate | bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase. The cytidylyltransferase is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors | Pyrococcus furiosus | ? | - |
? | |
| CDP-D-myo-inositol + 1L-myo-inositol 1-phosphate | bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase. The cytidylyltransferase is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors | Thermococcus kodakarensis | ? | - |
? | |
| CDP-D-myo-inositol + 1L-myo-inositol 1-phosphate | bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase. The cytidylyltransferase is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors | Aquifex aeolicus | ? | - |
? | |
| CDP-glycerol + 1D-myo-inositol 3-phosphate | bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase. The cytidylyltransferase is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors | Pyrococcus furiosus | CMP + myo-L-inositol 1,1'-phosphoglycerol | - |
? | |
| CDP-glycerol + 1D-myo-inositol 3-phosphate | bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase. The cytidylyltransferase is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors | Thermococcus kodakarensis | CMP + myo-L-inositol 1,1'-phosphoglycerol | - |
? | |
| CDP-glycerol + 1D-myo-inositol 3-phosphate | bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase. The cytidylyltransferase is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors | Aquifex aeolicus | CMP + myo-L-inositol 1,1'-phosphoglycerol | - |
? | |
| CDP-glycerol + 1L-myo-inositol 1-phosphate | bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase. The cytidylyltransferase is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors | Archaeoglobus fulgidus | CMP + 1L-(1X-glyceryl)-myo-inositol phosphate 3-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CDP-inositol:inositol-1-phosphate transferase | bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS) | Archaeoglobus fulgidus |
| CDP-inositol:inositol-1-phosphate transferase | bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS) | Pyrococcus furiosus |
| CDP-inositol:inositol-1-phosphate transferase | bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS) | Thermococcus kodakarensis |
| CDP-inositol:inositol-1-phosphate transferase | bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS) | Aquifex aeolicus |
| DIPPS | bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS) | Archaeoglobus fulgidus |
| DIPPS | bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS) | Pyrococcus furiosus |
| DIPPS | bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS) | Thermococcus kodakarensis |
| DIPPS | bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS) | Aquifex aeolicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 80 | - |
assay at | Archaeoglobus fulgidus |
| 80 | - |
assay at | Pyrococcus furiosus |
| 80 | - |
assay at | Thermococcus kodakarensis |
| 80 | - |
assay at | Aquifex aeolicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.6 | - |
assay at | Archaeoglobus fulgidus |
| 7.6 | - |
assay at | Pyrococcus furiosus |
| 7.6 | - |
assay at | Thermococcus kodakarensis |
| 7.6 | - |
assay at | Aquifex aeolicus |
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