Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.8.29 extracted from

  • Arikketh, D.; Nelson, R.; Vance, J.E.
    Defining the importance of phosphatidylserine synthase-1 (PSS1): unexpected viability of PSS1-deficient mice (2008), J. Biol. Chem., 283, 12888-12897.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

General Information

General Information Comment Organism
physiological function intercrosses of mice lacking PSS1, EC 2.7.8.8, and PSS2-/- mice yield mice with three disrupted Pss alleles but no double knockout mice. In PSS1-/-PSS2+/- and PSS1+/-PSS2-/- mice, serine exchange activity is reduced by 65-91%,and the tissue content of phosphatidylserine and phosphatidylethanolamine is also decreased. Elimination of either PSS1 or PSS2, but not both, is compatible with mouse viability, mice can tolerate as little as 10% of normal total serine-exchange activity, and mice survive with significantly reduced phosphatidylserine and phosphatidylethanolamine content Mus musculus