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Literature summary for 2.7.8.27 extracted from

  • Hu, S.; Ding, Y.; Gong, J.; Yan, N.
    Sphingomyelin synthase 2 affects CD14-associated induction of NF kappaB by lipopolysaccharides in acute lung injury in mice (2016), Mol. Med. Rep., 14, 3301-3306.
    View publication on PubMed
Search for more literature for 2.7.8.27

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane lipid raft Mus musculus 16020
-

Organism

Organism UniProt Comment Textmining
Mus musculus Q9D4B1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Mus musculus
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Synonyms

Synonyms Comment Organism
SM synthase
-
 Mus musculus
SMS2
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 Mus musculus
sphingomyelin synthase 2
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus lipopolysaccharide induction analyzed in an ALI mouse model, compared with the control group, the mRNA and protein levels of CD14 are significantly increased, and the activity of SMS and expression of SMS2 are significantly upregulated in the model group up

General Information

General Information Comment Organism
physiological function sphingomyelin synthase (SMS) is a key enzyme in the synthesis of sphingomyelin. Effect of SMS on the inflammatory pathway involving nuclear factor (NF)kappaB induced by lipopolysaccharide is analyzed in an ALI mouse model, overview. Compared with the control group, the mRNA and protein levels of CD14 are significantly increased, and the activity of SMS and expression of SMS2 are significantly upregulated in the model group. The expression of SMS2 may affect the induction of the NFkappaB pathway by LPS through CD14 Mus musculus