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Literature summary for 2.7.8.27 extracted from
- Modeling sphingomyelin synthase 1 driven reaction at the Golgi apparatus can explain data by inclusion of a positive feedback mechanism (2013), J. Theor. Biol., 337, 174-180.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| Golgi apparatus | - |
Homo sapiens | 5794 | - |
| membrane | - |
Homo sapiens | 16020 | - |
| trans-Golgi network | - |
Homo sapiens | 5802 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| a ceramide + a phosphatidylcholine | Homo sapiens | - |
a sphingomyelin + a 1,2-diacyl-sn-glycerol | - |
r |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q86VZ5 | - |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| a ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol | positive feedback mechanism from the products to the reactants, in vivo via protein kinase D and the ceramide transfer protein CERT, modeling | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| a ceramide + a phosphatidylcholine | - |
Homo sapiens | a sphingomyelin + a 1,2-diacyl-sn-glycerol | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SMS1 | - |
Homo sapiens |
| sphingomyelin synthase 1 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| additional information | minimal mathematical model for the sphingomyelin synthase 1 (SMS1) driven conversion of ceramide to sphingomyelin based on chemical reaction kinetics, modeling sphingomyelin synthase 1 driven reaction at the Golgi apparatus can explain data by inclusion of a positive feedback mechanism, this model is not able to qualitatively reproduce experimental measurements on lipid compositions after altering SMS1 activity, overview | Homo sapiens |
| physiological function | role of SMSs in vesicular trafficking from the Golgi to the plasma membrane | Homo sapiens |
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Release 2023.1 (January 2023)
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