Application | Comment | Organism |
---|---|---|
drug development | enzyme SMS1 is a drug target for the treatment of atherosclerosis | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene SGMS1, recombinnat overexpression of isozyme SMS1 in HeLa cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(2-(benzyloxy)phenyl)-2-(phenylamino) acetonitrile | - |
Homo sapiens | |
2-(4-(N-phenethylsulfamoyl)phenoxy)-N-(2-(trifluoromethoxy)phenyl)acetamide | - |
Homo sapiens | |
2-(4-(N-phenethylsulfamoyl)phenoxy)-N-(o-tolyl)acetamide | - |
Homo sapiens | |
2-(4-(N-phenethylsulfamoyl)phenoxy)-N-phenylacetamide | - |
Homo sapiens | |
4-(2-((4-chlorobenzyl)amino)-2-oxoethoxy)-N-(pyridin-4-yl)benzamide | - |
Homo sapiens | |
4-(2-((4-chlorobenzyl)amino)-2-oxoethoxy)-N-phenethylbenzamide | - |
Homo sapiens | |
additional information | structure-based virtual screening, synthesis and biological evaluation of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) as sphingomyelin synthase 1 inhibitors, molecular docking studies and interaction modes of SMS1 inhibitors with the active site of SMS1, overview | Homo sapiens | |
N-(2-cyanophenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | - |
Homo sapiens | |
N-(2-methoxyphenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | - |
Homo sapiens | |
N-(2-nitrophenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | - |
Homo sapiens | |
N-(3-fluorobenzyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | - |
Homo sapiens | |
N-(3-methoxyphenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | - |
Homo sapiens | |
N-(4-bromobenzyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | - |
Homo sapiens | |
N-(4-chlorobenzyl)-2-(4-(N-(3-phenylpropyl)sulfamoyl)phenoxy)acetamide | - |
Homo sapiens | |
N-(4-chlorobenzyl)-2-(4-(N-(4-chlorobenzyl)sulfamoyl)phenoxy)acetamide | - |
Homo sapiens | |
N-(4-chlorobenzyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | - |
Homo sapiens | |
N-(4-chlorobenzyl)-2-(4-(N-phenylsulfamoyl)phenoxy)acetamide | - |
Homo sapiens | |
N-(4-chlorophenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | - |
Homo sapiens | |
N-(4-fluoro-2-methoxyphenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | - |
Homo sapiens | |
N-(4-fluorobenzyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | - |
Homo sapiens | |
N-(4-fluorophenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | - |
Homo sapiens | |
N-(4-methoxybenzyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | - |
Homo sapiens | |
N-(4-methoxyphenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | - |
Homo sapiens | |
N-benzyl-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | - |
Homo sapiens | |
N-phenethyl-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | - |
Homo sapiens | |
tricyclodecan-9-yl-xanthogenate | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
trans-Golgi network | - |
Homo sapiens | 5802 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
a ceramide + a phosphatidylcholine | Homo sapiens | - |
a sphingomyelin + a 1,2-diacyl-sn-glycerol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q86VZ5 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | SMS1 is the major SMS | Homo sapiens | - |
additional information | SMS isoform SMS1 is expressed ubiquitously in all the tested tissues | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a ceramide + a phosphatidylcholine | - |
Homo sapiens | a sphingomyelin + a 1,2-diacyl-sn-glycerol | - |
? | |
a ceramide + a phosphatidylcholine | substrate C6-NBD-ceramide, molecular docking studies and interaction modes of phosphatidylcholine with the active site of SMS1, overview | Homo sapiens | a sphingomyelin + a 1,2-diacyl-sn-glycerol | detection and quantifcation of C6-NBD-sphingomyelin by HPLC using the reversed-phase C18 column and an isocratic elution with methanol/water/trifluoroacetic acid (89:11:0.1 (v/v)) | ? |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylcholine:ceramide cholinephosphotransferase 1 | - |
Homo sapiens |
SGMS1 | - |
Homo sapiens |
SMS1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0021 | - |
pH 7.4, 37°C | Homo sapiens | N-(4-bromobenzyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | |
0.0052 | - |
pH 7.4, 37°C | Homo sapiens | N-(4-chlorobenzyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | |
0.0059 | - |
pH 7.4, 37°C | Homo sapiens | N-(4-methoxybenzyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | |
0.0066 | - |
pH 7.4, 37°C | Homo sapiens | N-(4-chlorophenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | |
0.0081 | - |
pH 7.4, 37°C | Homo sapiens | N-(4-fluorobenzyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | |
0.0092 | - |
pH 7.4, 37°C | Homo sapiens | N-(3-methoxyphenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | |
0.0105 | - |
pH 7.4, 37°C | Homo sapiens | N-(4-fluorophenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | |
0.0142 | - |
pH 7.4, 37°C | Homo sapiens | N-(2-methoxyphenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | |
0.0147 | - |
pH 7.4, 37°C | Homo sapiens | 2-(4-(N-phenethylsulfamoyl)phenoxy)-N-phenylacetamide | |
0.0156 | - |
pH 7.4, 37°C | Homo sapiens | N-(3-fluorobenzyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | |
0.0231 | - |
pH 7.4, 37°C | Homo sapiens | N-benzyl-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | |
0.025 | - |
pH 7.4, 37°C | Homo sapiens | 2-(2-(benzyloxy)phenyl)-2-(phenylamino) acetonitrile | |
0.05 | - |
pH 7.4, 37°C | Homo sapiens | N-(4-chlorobenzyl)-2-(4-(N-(4-chlorobenzyl)sulfamoyl)phenoxy)acetamide | |
0.05 | - |
pH 7.4, 37°C | Homo sapiens | N-phenethyl-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | |
0.05 | - |
pH 7.4, 37°C | Homo sapiens | N-(4-methoxyphenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | |
0.1 | - |
pH 7.4, 37°C | Homo sapiens | 4-(2-((4-chlorobenzyl)amino)-2-oxoethoxy)-N-phenethylbenzamide | |
0.1 | - |
pH 7.4, 37°C | Homo sapiens | 4-(2-((4-chlorobenzyl)amino)-2-oxoethoxy)-N-(pyridin-4-yl)benzamide | |
0.1 | - |
pH 7.4, 37°C | Homo sapiens | N-(4-chlorobenzyl)-2-(4-(N-(3-phenylpropyl)sulfamoyl)phenoxy)acetamide | |
0.1 | - |
pH 7.4, 37°C | Homo sapiens | N-(4-chlorobenzyl)-2-(4-(N-phenylsulfamoyl)phenoxy)acetamide | |
0.1 | - |
pH 7.4, 37°C | Homo sapiens | 2-(4-(N-phenethylsulfamoyl)phenoxy)-N-(o-tolyl)acetamide | |
0.1 | - |
pH 7.4, 37°C | Homo sapiens | N-(2-nitrophenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | |
0.1 | - |
pH 7.4, 37°C | Homo sapiens | N-(2-cyanophenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | |
0.1 | - |
pH 7.4, 37°C | Homo sapiens | 2-(4-(N-phenethylsulfamoyl)phenoxy)-N-(2-(trifluoromethoxy)phenyl)acetamide | |
0.1 | - |
pH 7.4, 37°C | Homo sapiens | N-(4-fluoro-2-methoxyphenyl)-2-(4-(N-phenethylsulfamoyl)phenoxy)acetamide | |
0.219 | - |
pH 7.4, 37°C | Homo sapiens | tricyclodecan-9-yl-xanthogenate |