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Literature summary for 2.7.8.27 extracted from
- Differential effect of 2-hydroxyoleic acid enantiomers on protein (sphingomyelin synthase) and lipid (membrane) targets (2014), Biochim. Biophys. Acta, 1838, 1628-1637.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| (S)-2-hydroxyoleic acid | a complex dual mechanism of action of 2-hydroxyoleic acid (2OHOA) as potent anti-tumor compound used in membrane lipid therapy (MLT). Only the S-enantiomer is able to activate enzyme SMS in human glioma U118 cells. The anti-tumor efficacy of the S-enantiomer is greater than that of the R-enantiomer, as the former can act through both membrane lipid therapy mechanisms, type-1 and type-2 MLT approaches. Molecular dynamics study indicates that both enantiomers interact similarly with lipid bilayers, molecular dynamics simulation, overview | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| glioma cell | - |
Homo sapiens | - |
| U-118MG cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SMS | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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