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Literature summary for 2.7.8.27 extracted from

  • Qureshi, A.; Subathra, M.; Grey, A.; Schey, K.; Del Poeta, M.; Luberto, C.
    Role of sphingomyelin synthase in controlling the antimicrobial activity of neutrophils against Cryptococcus neoformans (2010), PLoS ONE, 5, e15587.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.8.27

Inhibitors

Inhibitors Comment Organism Structure
D609
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
-
 Homo sapiens
-
neutrophil
-
 Homo sapiens
-

General Information

General Information Comment Organism
malfunction inhibition of sphingomyelin synthase activity profoundly impairs the killing ability of neutrophils against Cryptococcus neoformans by preventing the extracellular release of an antifungal factors Homo sapiens
physiological function the enzyme plays a key role in the regulation of the killing activity of neutrophils against Cryptococcus neoformans through a diacylglycerol-protein kinase D dependent mechanism Homo sapiens