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Literature summary for 2.7.8.27 extracted from
- Regulation of cell migration by sphingomyelin synthases: sphingomyelin in lipid rafts decreases responsiveness to signaling by the CXCL12/CXCR4 pathway (2012), Mol. Cell. Biol., 32, 3242-3252.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| MEF cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylcholine + C6-ceramide | - |
Mus musculus | C6-sphingomyelin + 1,2-diacyl-sn-glycerol | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SMS | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | sphingomyelin synthase (SMS) deficiency promotes cell migration through a CXCL12/CXCR4-dependent signaling pathway involving extracellular signal-regulated kinase activation. In addition, SMS1/SMS2 double-knockout cells have heightened sensitivity to CXCL12. SMS deficiency facilitates relocalization of CXCR4 to lipid rafts, which form platforms for the regulation and transduction of receptor-mediated signaling. Furthermore, SMS deficiency potentiates CXCR4 dimerization, which is required for signal transduction | Mus musculus |
| physiological function | sphingomyelin synthase-generated sphingomyelin is involed in the regulation of cell migration | Mus musculus |
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Release 2023.1 (January 2023)
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