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Literature summary for 2.7.8.27 extracted from

  • Chen, Y.; Yurek, D.A.; Yu, L.; Wang, H.; Ehsani, M.E.; Qian, Y.W.; Konrad, R.J.; Jiang, X.C.; Kuo, M.S.; Cao, G.; Wang, J.
    Development of a quantitative biochemical and cellular sphingomyelin synthase assay using mass spectrometry (2013), Anal. Biochem., 438, 61-66.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in in Sf9 insect cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
D609
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00538
-
C8-ceramide isoform SMS1, in 50 mM Tris–HCl (pH 7.4), at 22°C Homo sapiens
0.005549
-
C8-ceramide isoform SMS1, in 50 mM Tris–HCl (pH 7.4), at 22°C Homo sapiens
0.006277
-
C6-ceramide isoform SMS2, in 50 mM Tris–HCl (pH 7.4), at 22°C Homo sapiens
0.007235
-
C6-ceramide isoform SMS2, in 50 mM Tris–HCl (pH 7.4), at 22°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
54000
-
x * 54000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidylcholine + ceramide Homo sapiens
-
sphingomyelin + 1,2-diacyl-sn-glycerol
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q86VZ5 isoform SMS1
-
Homo sapiens Q8NHU3 isoform SMS2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylcholine + C6-ceramide
-
Homo sapiens C6-sphingomyelin + 1,2-diacyl-sn-glycerol
-
?
phosphatidylcholine + C8-ceramide
-
Homo sapiens C7-sphingomyelin + 1,2-diacyl-sn-glycerol
-
?
phosphatidylcholine + ceramide
-
Homo sapiens sphingomyelin + 1,2-diacyl-sn-glycerol
-
?

Subunits

Subunits Comment Organism
? x * 54000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
SMS1 isoform Homo sapiens
SMS2 isoform Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.622
-
isoform SMS1, in 50 mM Tris–HCl (pH 7.4), at 22°C Homo sapiens D609
1.065
-
isoform SMS2, in 50 mM Tris–HCl (pH 7.4), at 22°C Homo sapiens D609