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Literature summary for 2.7.8.27 extracted from
- Macrophage sphingomyelin synthase 2 deficiency decreases atherosclerosis in mice (2009), Circ. Res., 105, 295-303.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | SMS2 is a potential therapeutic target for treatment of atherosclerosis | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ceramide + phosphatidylcholine | Mus musculus | - |
sphingomyelin + 1,2-diacyl-sn-glycerol | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| macrophage | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ceramide + phosphatidylcholine | - |
Mus musculus | sphingomyelin + 1,2-diacyl-sn-glycerol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SMS2 | - |
Mus musculus |
| sphingomyelin synthase 2 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | SMS2 deficiency causes significant induction of cholesterol efflux in vitro and in vivo, SMS2 deficiency in the macrophages reduces atherosclerosis in mice | Mus musculus |
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Release 2023.1 (January 2023)
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