Cloned (Comment) | Organism |
---|---|
gene SMS1, expression in Jurkat cells, expression levels, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | knockout of SMS1 in T-cells by transfection of SMS1-short-interfering RNA into Jurkat T cells, impaired TCR signaling through dysfunction of lipid rafts in SMS1-knockdown T cells, overview. CD3-induced tyrosine phosphorylation and association of linker for activation of T cell with ZAP-70 and Grb2 and phosphorylation of protein kinase C are also severely impaired in Jurkat-SMS1/kd cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
lysenin | is a sphingomyelin-directed cytolysin purified from the earthworm, which specifically binds to membrane sphingomyelin and induces pore formation in the plasma membrane and subsequent cell death | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | membrane sphingomyelin is a key component of lipid rafts involved in TCR signal transduction, physiological functions of sphingomyelin, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
gene SMS1 encoding isozyme SMS1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
T-lymphocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | membrane sphingomyelin is a key component of lipid rafts involved in TCR signal transduction, physiological functions of sphingomyelin, overview | Homo sapiens | ? | - |
? | |
phosphatidylcholine + C6-NBD-ceramide | i.e. N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphingosine, the fluorogenic derivative of C6-ceramide | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SMS1 | - |
Homo sapiens |
sphingomyelin synthase 1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |