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Literature summary for 2.7.8.27 extracted from

  • Separovic, D.; Semaan, L.; Tarca, A.L.; Awad Maitah, M.Y.; Hanada, K.; Bielawski, J.; Villani, M.; Luberto, C.
    Suppression of sphingomyelin synthase 1 by small interference RNA is associated with enhanced ceramide production and apoptosis after photodamage (2008), Exp. Cell Res., 314, 1860-1868.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.8.27

Protein Variants

Protein Variants Comment Organism
additional information overexpression of SMS1 is accompanied by attenuated ceramide response and apoptotic resistance after photodamage with the photosensitizer Pc 4, while suppression of SMS1 by small interference RNA is associated with enhanced ceramide production and apoptosis after photodamage, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens SMS1 converts de novo ceramide into sphingomyelin, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozyme SMS1
-

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell clone E6-1 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information SMS1 converts de novo ceramide into sphingomyelin, overview Homo sapiens ?
-
 ?
phosphatidylcholine + C6-ceramide
-
 Homo sapiens ?
-
 ?
phosphatidylcholine + C6-NBD-ceramide i.e. N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphingosine, the fluorogenic derivative of C6-ceramide Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
SMS1
-
 Homo sapiens
sphingomyelin synthase 1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens