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Literature summary for 2.7.8.27 extracted from

  • Separovic, D.; Hanada, K.; Maitah, M.Y.; Nagy, B.; Hang, I.; Tainsky, M.A.; Kraniak, J.M.; Bielawski, J.
    Sphingomyelin synthase 1 suppresses ceramide production and apoptosis post-photodamage (2007), Biochem. Biophys. Res. Commun., 358, 196-202.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.8.27

Cloned(Commentary)

Cloned (Comment) Organism
stable overexpression of SMS1 in Jurkat cells leading to a 3.8fold increase in SMS activity Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information overexpression of SMS1 in Jurkat cells leads to suppression of the production of dihydroceramides and dihydrosphingosine, and ceramide Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information photosensitizer Pc 4, PDT, induces inhibition of SMS in Jurkat cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi membrane isozyme SMS1 Homo sapiens 139
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens SMS1 suppresses ceramide production and apoptosis post-photodamage ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozyme SMS1
-

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell clone E6-1 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information SMS1 suppresses ceramide production and apoptosis post-photodamage Homo sapiens ?
-
 ?
phosphatidylcholine + C6-ceramide
-
 Homo sapiens ?
-
 ?
phosphatidylcholine + C6-NBD-ceramide i.e. N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphingosine, the fluorogenic derivative of C6-ceramide Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
SMS1
-
 Homo sapiens
sphingomyelin synthase 1
-
 Homo sapiens