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Literature summary for 2.7.8.27 extracted from

  • Hailemariam, T.K.; Huan, C.; Liu, J.; Li, Z.; Roman, C.; Kalbfeisch, M.; Bui, H.H.; Peake, D.A.; Kuo, M.; Cao, G.; Wadgaonkar, R.; Jiang, X.
    Sphingomyelin synthase 2 deficiency attenuates NFkappaB activation (2008), Arterioscler. Thromb. Vasc. Biol., 28, 1519-1526.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information sphingomyelin synthase 2 deficiency, due to siRNA treatment of HEK-293 cells, attenuates NFkappaB activation, it impairs TNF receptor 1 recruitment tolipid rafts and TLR4-MD2 complex recruitment to plasma membrane Homo sapiens
additional information sphingomyelin synthase 2 knockout deficiency attenuates NFkappaB activation, it impairs TNF receptor 1 recruitment tolipid rafts and TLR4-MD2 complex recruitment to plasma membrane Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane SMS2, predominantly Mus musculus 5886
-
plasma membrane SMS2, predominantly Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus SMS2 regulates sphingomyelin levels in plasma membrane and lipid rafts and has a potential to regulate NFkappaB activation, via multiple mechanisms, overview ?
-
?
additional information Homo sapiens SMS2 regulates sphingomyelin levels in plasma membrane and lipid rafts and has a potential to regulate NFkappaB activation, via multiple mechanisms, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozyme SMS2
-
Mus musculus
-
isozyme SMS2
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-
macrophage
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information SMS2 regulates sphingomyelin levels in plasma membrane and lipid rafts and has a potential to regulate NFkappaB activation, via multiple mechanisms, overview Mus musculus ?
-
?
additional information SMS2 regulates sphingomyelin levels in plasma membrane and lipid rafts and has a potential to regulate NFkappaB activation, via multiple mechanisms, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
SMS2
-
Mus musculus
SMS2
-
Homo sapiens
sphingomyelin synthase 2
-
Mus musculus
sphingomyelin synthase 2
-
Homo sapiens