Protein Variants | Comment | Organism |
---|---|---|
additional information | sphingomyelin synthase 2 deficiency, due to siRNA treatment of HEK-293 cells, attenuates NFkappaB activation, it impairs TNF receptor 1 recruitment tolipid rafts and TLR4-MD2 complex recruitment to plasma membrane | Homo sapiens |
additional information | sphingomyelin synthase 2 knockout deficiency attenuates NFkappaB activation, it impairs TNF receptor 1 recruitment tolipid rafts and TLR4-MD2 complex recruitment to plasma membrane | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | SMS2, predominantly | Mus musculus | 5886 | - |
plasma membrane | SMS2, predominantly | Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | SMS2 regulates sphingomyelin levels in plasma membrane and lipid rafts and has a potential to regulate NFkappaB activation, via multiple mechanisms, overview | ? | - |
? | |
additional information | Homo sapiens | SMS2 regulates sphingomyelin levels in plasma membrane and lipid rafts and has a potential to regulate NFkappaB activation, via multiple mechanisms, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme SMS2 | - |
Mus musculus | - |
isozyme SMS2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
macrophage | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | SMS2 regulates sphingomyelin levels in plasma membrane and lipid rafts and has a potential to regulate NFkappaB activation, via multiple mechanisms, overview | Mus musculus | ? | - |
? | |
additional information | SMS2 regulates sphingomyelin levels in plasma membrane and lipid rafts and has a potential to regulate NFkappaB activation, via multiple mechanisms, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SMS2 | - |
Mus musculus |
SMS2 | - |
Homo sapiens |
sphingomyelin synthase 2 | - |
Mus musculus |
sphingomyelin synthase 2 | - |
Homo sapiens |