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Literature summary for 2.7.8.27 extracted from

  • Dong, J.; Liu, J.; Lou, B.; Li, Z.; Ye, X.; Wu, M.; Jiang, X.C.
    Adenovirus-mediated overexpression of sphingomyelin synthases 1 and 2 increases the atherogenic potential in mice (2006), J. Lipid Res., 47, 1307-1314.
    View publication on PubMed
Search for more literature for 2.7.8.27

Application

Application Comment Organism
medicine adenovirus-mediated SMS1 overexpression increases lipoprotein atherogenic potential. Such an effect may contribute to the increased plasma sphingomyelin levels observed in animal models of atherosclerosis and in human patients with coronary artery disease Mus musculus
medicine adenovirus-mediated SMS2 overexpression increases lipoprotein atherogenic potential. Such an effect may contribute to the increased plasma sphingomyelin levels observed in animal models of atherosclerosis and in human patients with coronary artery disease Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
adenovirus approach to overexpress SMS1 in mice to investigate the relationship between sphingomyelin synthase and sphingomyelin metabolism Mus musculus
adenovirus approach to overexpress SMS2 in mice to investigate the relationship between sphingomyelin synthase and sphingomyelin metabolism Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q8VCQ6
-
-
Mus musculus Q9D4B1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)hexanoyl)sphingosine + phosphatidylcholine
-
 Mus musculus N-hexanoyl-4-nitrobenz-2-oxa-1,3-diazole-sphingomyelin + 1,2-diacylglycerol
-
 ?

Synonyms

Synonyms Comment Organism
SMS1
-
 Mus musculus
SMS2
-
 Mus musculus
sphingomyelin synthases 1
-
 Mus musculus
sphingomyelin synthases 2
-
 Mus musculus