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Literature summary for 2.7.8.27 extracted from
- Reverse sphingomyelin-synthase in rat liver chromatin (2003), FEBS Lett., 549, 152-156.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0356 | - |
sphingomyelin | - |
Rattus norvegicus |  |
| 0.112 | - |
diacylglycerol | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| chromatin | high activity. The presence of sphingomyelin synthase in chromatin may have a relevant influence in regulating the diacylglycerol/ceramide ratio at this particular subcellular level | Rattus norvegicus | 785 | - |
| cytosol | low activity | Rattus norvegicus | 5829 | - |
| nuclear membrane | low activity | Rattus norvegicus | 31965 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sphingomyelin + diacylglycerol | - |
Rattus norvegicus | ceramide + phosphatidylcholine | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.4 | - |
- |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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