Literature summary for 2.7.8.27 extracted from

Meng, A.; Luberto, C.; Meier, P.; Bai, A.; Yang, X.; Hannun, Y.A.; Zhou, D.
Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells (2004), Exp. Cell Res., 292, 385-392.

Search for more literature for 2.7.8.27

Application

Application	Comment	Organism
medicine	sphingomyelin synthase is a potential target for tricyclodecan-9-yl-xanthogenate (D609) and inhibition of sphingomyelin synthase may contribute to D609-induced cell death via modulation of the cellular levels of ceramide and diacylglycerol	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
tricyclodecan-9-yl-xanthogenate	sphingomyelin synthase is a potential target for tricyclodecan-9-yl-xanthogenate (D609) and inhibition of sphingomyelin synthase may contribute to D609-induced cell death via modulation of the cellular levels of ceramide and diacylglycerol	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
U-937 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)