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Literature summary for 2.7.8.2 extracted from

  • Sinha Roy, S.; Mukhopadhyay, S.; Mukherjee, S.; Das, S.K.
    Breast cancer is associated with an increase in the activity and expression of cholinephosphotransferase in rats (2008), Life Sci., 83, 661-665.
    View publication on PubMed
Search for more literature for 2.7.8.2

Application

Application Comment Organism
medicine cholinephosphotransferase can be used as a biomarker for breast cancer in an animal model Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CDP-choline + 1,2-diacyl-sn-glycerol Rattus norvegicus
-
 CMP + phosphatidylcholine
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 female Sprague Dawley rat
-

Source Tissue

Source Tissue Comment Organism Textmining
breast
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 0.4 nmol/mg protein, normal breast tissue Rattus norvegicus
additional information
-
 0.8 nmol/mg protein, dimethylbenz(alpha)anthracene induced tumor Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CDP-choline + 1,2-diacyl-sn-glycerol
-
 Rattus norvegicus CMP + phosphatidylcholine
-
 ?

Synonyms

Synonyms Comment Organism
cholinephosphotransferase
-
 Rattus norvegicus
CPT
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus cholinephosphotransferase activity and its expression are significantly higher in breast cancer tissues up

General Information

General Information Comment Organism
physiological function cholinephosphotransferase is the terminal enzyme for the de novo biosynthesis of phosphatidylcholine Rattus norvegicus