Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.8.2 extracted from

  • Wright, M.M.; McMaster, C.R.
    PC and PE synthesis: mixed micellar analysis of the cholinephosphotransferase and ethanolaminephosphotransferase activities of human choline/ethanolamine phosphotransferase 1 (CEPT1) (2002), Lipids, 37, 663-672.
    View publication on PubMed
Search for more literature for 2.7.8.2

Inhibitors

Inhibitors Comment Organism Structure
chelerythrine inhibitor of protein kinase C, IC50 0.04 mM Homo sapiens
R59949 inhibitor of protein kinase C, IC50 0.04 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.036
-
 CDP-choline 25°C, pH 8.0 Homo sapiens
0.098
-
 CDP-ethanolamine 25°C, pH 8.0 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 dual-specificity enzyme, activitiy of EC 2.7.8.1 and EC 2.7.8.2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CDP-choline + 1,2-diacylglycerol preferred substrates: di-18:1-diacylglycerol, di-16:1-diacylglycerol, 16:0/18:1-diacylglycerol, 16:0/22:6-diacylglycerol Homo sapiens CMP + a phosphatidylcholine
-
 ?
CDP-ethanolamine + 1,2-diacylglycerol preferred substrates: 16:0/18:1 diacylglycerol, di-18:1 diacylglycerol, di-18:1 diacylglycerol Homo sapiens CMP + phosphatidylethanolamine
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.04
-
 inhibitor of protein kinase C, IC50 0.04 mM Homo sapiens R59949
0.04
-
 inhibitor of protein kinase C, IC50 0.04 mM Homo sapiens chelerythrine