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Literature summary for 2.7.8.2 extracted from

  • Henneberry, A.L.; McMaster, C.R.
    Cloning and expression of a human choline/ethanolaminephosphotransferase: synthesis of phosphatidylcholine and phosphatidylethanolamine (1999), Biochem. J., 339, 291-298.
No PubMed abstract available
Search for more literature for 2.7.8.2

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Mn2+ inhibitory above 10 mM, activation below Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.037
-
 CDP-choline cosubstrate di-18:1-diacylglycerol, 20°C, pH 8.0 Homo sapiens
0.101
-
 CDP-ethanolamine cosubstrate di-18:1-diacylglycerol, 20°C, pH 8.0 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activates, acts mostly on cholinephosphotransferase activity Homo sapiens
Mn2+ activates, acts mostly on ethanolaminephosphotransferase activity, inhibitory above 10 mM Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
46500
-
 x * 46500, hCEPT1, SDS-PAGE and deduced from gene sequence, seven membrane-spanning helices Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 dual-specificity enzyme, activitiy of EC 2.7.8.1 and EC 2.7.8.2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CDP-choline + 1,2-diacylglycerol preferred substrates in decreasing order: di-10:0 diacylglycerol, di-16:1 diacylglycerol, di-8:0 diacylglycerol, di-18:1 diacylglycerol, 16:0/22:6 diacylglycerol Homo sapiens CMP + a phosphatidylcholine
-
 ?
CDP-ethanolamine + 1,2-diacylglycerol preferred substrates in decreasing order: di-18:1 diacylglycerol, di-16:1 diacylglycerol, 16:0/18:1 diacylglycerol, 16:0/22:6 diacylglycerol Homo sapiens CMP + phosphatidylethanolamine
-
 ?

Subunits

Subunits Comment Organism
? x * 46500, hCEPT1, SDS-PAGE and deduced from gene sequence, seven membrane-spanning helices Homo sapiens