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Literature summary for 2.7.8.2 extracted from
- 1,2-Diacylglycerol: CDPcholine cholinephosphotransferase (1981), Methods Enzymol., 71, 536-546.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| deoxycholate | stimulates, inhibition above 2 mM | Rattus norvegicus |  |
| phosphatidylcholine | activates | Rattus norvegicus | |
| Phospholipids | total microsomal phospholipids stimulate | Rattus norvegicus | |
| taurocholate | stimulates | Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CDPethanolamine | - |
Rattus norvegicus | |
| CMPcholine | product inhibition | Rattus norvegicus | |
| deoxycholate | stimulates, inhibition above 2 mM | Rattus norvegicus | |
| Triton X-100 | activity assayed with Mg2+ is more labile than that assayed with Mn2+; X-100 | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | cytoplasmic face of microsomal vesicles | Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Rattus norvegicus | |
| Mn2+ | can partially replace Mg2+ in activation | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CDP-choline + 1,2-diacylglycerol | - |
Rattus norvegicus | CMP + a phosphatidylcholine | - |
r | |
| CDP-choline + 1,2-dipalmitoyl-sn-glycerol | poor substrate | Rattus norvegicus | CMP + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine | - |
? | |
| CMP + phosphatidylcholine | - |
Rattus norvegicus | CDP-choline + 1,2-diacylglycerol | - |
r | |
| additional information | 1-acyl-2-oleoylglycerols, ranging from 1-lauroyl to 1-heptadecanoyl species are equally well utilized, fully saturated diacylglycerols like dipalmitoylglycerol are poorly utilized, several 1-oleoyl-2-saturated types of diacylglycerol are effectively used | Rattus norvegicus | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | 8.5 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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