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Literature summary for 2.7.8.2 extracted from
- Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor and a hypotensive lipid) by cholinephosphotransferase in various rat tissues (1981), Biochim. Biophys. Acta, 663, 545-556.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| dithiothreitol | slight enhancement of activity towards 1-alkyl-2-acetyl-sn-glycerol, inhibition of activity towards diacylglycerol | Rattus norvegicus |  |
General Stability
| General Stability | Organism |
|---|---|
| dithiothreitol stabilizes | Rattus norvegicus |
| no loss of activity by freezing and thawing one time | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dithiothreitol | slight enhancement of activity towards 1-alkyl-2-acetyl-sn-glycerol, inhibition of activity towards diacylglycerol | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | last step in de novo synthesis of diacylglycerophosphocholine | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| lung | fetal | Rattus norvegicus | - |
| spleen | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CDP-choline + 1,2-diacylglycerol | - |
Rattus norvegicus | CMP + a phosphatidylcholine | - |
? | |
| CDP-choline + 1-batyl-2-acetyl-sn-glycerol | - |
Rattus norvegicus | CMP + 1-batyl-2-acetyl-sn-glycero-3-phosphocholine | - |
? | |
| CDP-choline + 1-chimyl-2-acetyl-sn-glycerol | - |
Rattus norvegicus | CMP + 1-chimyl-2-acetyl-sn-glycero-3-phosphocholine | - |
? | |
| CDP-choline + 1-selachyl-2-acetyl-sn-glycerol | - |
Rattus norvegicus | CMP + 1-selachyl-2-acetyl-sn-glycero-3-phosphocholine | - |
? | |
| additional information | last step in de novo synthesis of diacylglycerophosphocholine | Rattus norvegicus | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine | Rattus norvegicus |
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Release 2023.1 (January 2023)
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