Any feedback?
Literature summary for 2.7.8.13 extracted from
- A-94964, a novel inhibitor of bacterial translocase I, produced by Streptomyces sp. SANK 60404. I. Taxonomy, isolation and biological activity (2008), J. Antibiot., 61, 537-544.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | translocase I is a target of antibiotics | Staphylococcus aureus |
| medicine | translocase I is a target of antibiotics | Enterococcus faecalis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| A-94964 | - |
Enterococcus faecalis |  |
| A-94964 | - |
Staphylococcus aureus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate | Staphylococcus aureus | - |
UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol | - |
? | |
| UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate | Enterococcus faecalis | - |
UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Enterococcus faecalis | - |
- |
- |
| Staphylococcus aureus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate | - |
Staphylococcus aureus | UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol | - |
? | |
| UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate | - |
Enterococcus faecalis | UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol | - |
? | |
| UDP-MurNAc-L-Ala-gamma-D-Glu-m-DAP-[Nepsilon-dansyl]-D-Ala-D-Ala + undecaprenyl phosphate | inhibitory assay | Staphylococcus aureus | UMP + MurNAc-L-Ala-gamma-D-Glu-m-DAP-[Nepsilon-dansyl]-D-Ala-D-Ala-diphosphoundecaprenol | - |
? | |
| UDP-MurNAc-L-Ala-gamma-D-Glu-m-DAP-[Nepsilon-dansyl]-D-Ala-D-Ala + undecaprenyl phosphate | inhibitory assay | Enterococcus faecalis | UMP + MurNAc-L-Ala-gamma-D-Glu-m-DAP-[Nepsilon-dansyl]-D-Ala-D-Ala-diphosphoundecaprenol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phospho-N-acetylmuramyl-pentapeptide translocase | - |
Staphylococcus aureus |
| phospho-N-acetylmuramyl-pentapeptide translocase | - |
Enterococcus faecalis |
| translocase I | - |
Staphylococcus aureus |
| translocase I | - |
Enterococcus faecalis |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
inhibitory assay at room temperature | Staphylococcus aureus |
| 22 | - |
inhibitory assay at room temperature | Enterococcus faecalis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
inhibitory assay | Staphylococcus aureus |
| 7.5 | - |
inhibitory assay | Enterococcus faecalis |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 1.1 | - |
MIC 100 microg/ml against Staphylococcus aureus | Staphylococcus aureus | A-94964 | |
| 1.1 | - |
MIC 50 microg/ml against Enterococcus faecalis | Enterococcus faecalis | A-94964 | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | translocase I is a key enzyme in peptidoglycan biosynthesis | Staphylococcus aureus |
| physiological function | translocase I is a key enzyme in peptidoglycan biosynthesis | Enterococcus faecalis |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
